ReviewVeterinary sciences2026
The Effects of Exercise on Fluorosis: A Comprehensive Multisystem Review.
Review in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Fluorosis, a systemic condition caused by chronic excessive fluoride intake, poses significant threats to livestock health and agricultural productivity worldwide. This systematic review synthesizes current evidence on the modulatory effects of exercise against fluorosis, integrating human studies, animal experiments, and methodological considerations. Human studies indicate negative associations between fluoride exposure and cognitive development, muscle function, and exercise capacity, with exercise influencing fluoride pharmacokinetics in an exercise-intensity-dependent manner. Animal experiments consistently demonstrate that regular moderate-intensity exercise attenuates fluoride-induced damage across multiple organ systems through activation of the Nrf2/ARE antioxidant pathway, modulation of BMP-2/Smads and OPG/RANKL/RANK signaling, suppression of inflammatory responses, and preservation of intestinal barrier integrity. Substantial heterogeneity exists among current fluorosis models regarding exposure dosages, durations, and exercise protocols, underscoring the need for standardization and consideration of genetic background. Overall, exercise shows promise for mitigating fluorosis-induced multi-organ damage, although human evidence remains limited. Future research should prioritize model optimization, elucidation of molecular targets, and exploration of synergistic interventions to provide a foundation for veterinary clinical management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.