ArticleVaccines2026
Incidence of COVID-19 and Influenza-Related Outcomes and Vaccinations in the United States, October 2022 Through December 2024.
Article in Vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
BACKGROUND/
objectivesWe still do not clearly know whether COVID-19 continues to impose a greater clinical burden than influenza in the "post-pandemic" era. Our study quantified and compared monthly COVID-19 and influenza hospitalization incidence among adult subgroups from October 2022 through December 2024. We assessed vaccine coverage trends and examined vaccination status among those hospitalized.
methodsUsing the Veradigm linked claims and electronic health record dataset, we conducted a non-interventional, retrospective cohort study; three monthly cohorts included individuals aged 65+, high-risk (HR) adults (defined as adults 18+ with HR conditions and/or aged 65+), and adults aged 50-64 years who were enrolled with both medical and pharmacy coverage. We estimated monthly cumulative incidence of COVID-19 and influenza-related hospitalizations, vaccination coverage rates, and the proportion of hospitalized individuals who had received yearly updated vaccines.
resultsCOVID-19 hospitalizations consistently exceeded those of influenza across months and populations. Among adults aged 65+, COVID-19 hospitalization rates were 2-3 times higher than influenza in winter and 20-30 times higher during off-season months, with similar trends observed in high risk adults. COVID-19 incidence surged in summer, while influenza remained seasonally confined. Vaccination coverage for influenza peaked near 50% annually; COVID-19 coverage was lower, peaking at ~26% by December each year. Most hospitalizations occurred among unvaccinated individuals, particularly for COVID-19.
conclusionsCOVID-19 continues to impose a substantial, year-round burden, particularly in older and high-risk adults, exceeding that of influenza. The high proportion of unvaccinated hospitalizations highlight a critical gap in prevention efforts and underscore the need for improved public health messaging and vaccine adoption.
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