ArticleTomography (Ann Arbor, Mich.)2026
Tensor-Valued Diffusion MRI for Microstructural Assessment During Stereotactic Radiotherapy of Brain Metastases: A Feasibility Study.
Article in Tomography (Ann Arbor, Mich.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesEarly identification of treatment response in brain metastases remains clinically challenging. This study explores tensor-valued diffusion MRI (dMRI), specifically q-space trajectory imaging (QTI), as a novel source of early imaging biomarkers during stereotactic radiotherapy (SRT).
methodsTwenty-six patients with brain metastases were enrolled; thirteen met quality and completeness criteria for QTI analysis (10 responders, three non-responders). MRI was acquired at four time points: before SRT, before final SRT fraction, and at 3 and 6 months post-SRT. QTI-derived metrics included mean diffusivity (MD), fractional anisotropy (FA), microscopic FA (µFA), and isotropic (MKI) and anisotropic (MKA) diffusional variance. Parameter values within the tumour volume were compared pre- and during SRT and correlated with treatment response from standard MRI follow-up. Overall survival was assessed using Kaplan-Meier analysis.
resultsMedian survival was 12 months. QTI analysis was feasible with visible changes in the tumour tissue parameter maps over time. Statistically significant differences (
conclusionsThis study presents a first exploration of QTI-derived parameters in a cohort of patients with brain metastases. We demonstrate feasibility and a scalable workflow, supporting further investigation in larger cohorts and in patients with larger or more stable lesions.
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