Evidence map›Paper›PMID 42188637›Full record

ArticleToxins2026

A Comprehensive Structural and Functional Analysis of

Jack W Creagh, Lily L Givens, David C Reetz, Sarah A Coss, Rodolfo Bizarria, Siti Aisyah Alias, Mohammed Rizman-Idid, Jagdish S Patel, Andre Rodrigues, F Marty Ytreberg and 1 more

Abstract read
In one paragraph

Article in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jack W CreaghDepartment of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.
Lily L GivensDepartment of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.
David C ReetzDepartment of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.
Sarah A CossDepartment of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.ORCID 0009-0002-4226-4744
Rodolfo BizarriaDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040, Brazil.ORCID 0000-0003-4293-5886
Siti Aisyah AliasInstitute of Ocean and Earth Sciences, C308, Institute of Advanced Studies Building, Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-6759-5745
Mohammed Rizman-IdidInstitute of Ocean and Earth Sciences, C308, Institute of Advanced Studies Building, Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-2231-2502
Jagdish S PatelDepartment of Chemical and Biological Engineering, University of Idaho, Moscow, ID 83844, USA.
Andre RodriguesDepartment of General and Applied Biology, Institute of Biosciences, São Paulo State University (UNESP), Rio Claro 13506, Brazil.ORCID 0000-0002-4164-9362
F Marty YtrebergInstitute for Modeling Collaboration and Innovation, University of Idaho, Moscow, ID 83844, USA.ORCID 0000-0001-7439-8224
Paul A RowleyDepartment of Biological Sciences, University of Idaho, Moscow, ID 83844, USA.ORCID 0000-0002-3590-5139

Funding

The Hypothesis Fund https://doi.org/10.13039/100031064
6 · The paper itself

Abstract

Antifungal killer toxins are cytotoxic proteins that have the potential to combat the growing threat of fungi to human health and agriculture. A lack of empirical tertiary structures has limited understanding of their mechanisms of action and their ability to target pathogens. In this study, AlphaFold and molecular dynamics simulations were used to generate tertiary structure models of all canonical

Indexed as

Antifungal AgentsKiller Factors, YeastSaccharomycesAmino Acid SequenceMolecular Dynamics SimulationProtein ConformationSaccharomyces cerevisiaeStructure-Activity RelationshipAntifungal AgentsKiller Factors, Yeastkiller toxinSaccharomycesyeast

Identifiers

PMID42188637
PMCPMC13211469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.