Evidence map›Paper›PMID 42188485›Full record

ArticleNanomaterials (Basel, Switzerland)2026

Transcriptomic Profiling of Toxic Copper Overload Induced by CuO Nanoparticles or Copper Ions in Human Lung Epithelial and Liver Cells.

Jana Kuhn, Anda R Gliga, Cheyenne Ines Aissouni, Anna Maria Glowacki, Marlene Parsdorfer, Martin Link, Hanna Lovisa Karlsson, Andrea Hartwig

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jana KuhnDepartment of Food Chemistry and Toxicology, Institute of Applied Biosciences (IAB), Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.ORCID 0000-0003-4840-3354
Anda R GligaUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Cheyenne Ines AissouniDepartment of Food Chemistry and Toxicology, Institute of Applied Biosciences (IAB), Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.
Anna Maria GlowackiUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Marlene ParsdorferDepartment of Food Chemistry and Toxicology, Institute of Applied Biosciences (IAB), Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.
Martin LinkDepartment of Food Chemistry and Toxicology, Institute of Applied Biosciences (IAB), Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.
Hanna Lovisa KarlssonDepartment of Pharmaceutical Biosciences, Uppsala Universitet, 751 24 Uppsala, Sweden.ORCID 0000-0002-4613-574X
Andrea HartwigDepartment of Food Chemistry and Toxicology, Institute of Applied Biosciences (IAB), Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.ORCID 0000-0003-3826-3319

Funding

Deutsche Forschungsgemeinschaft (DFG) HA 2372/15-1
6 · The paper itself

Abstract

The transition metal copper (Cu) is an essential trace element for humans and serves as a cofactor for numerous enzymes. Therefore, intracellular Cu homeostasis must be tightly regulated. Meanwhile, Cu is increasingly used in industrial and biomedical applications, particularly in nanoparticle (NP) form. However, studies have demonstrated that Cu(II) oxide (CuO) NPs are highly toxic. Therefore, understanding the underlying toxic effects of such compounds is of the utmost importance. In this context, transcriptomic profiling is regarded as a valuable tool. Nevertheless, comparative studies addressing organ-relevant models, such as the liver and lungs, are scarce. Furthermore, no transcriptomic studies have been conducted on human bronchial lung epithelial cells exposed to CuO NPs and Cu

Indexed as

copperin vitro researchnanotoxicologytranscriptomics

Identifiers

PMID42188485
PMCPMC13209870

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.