An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy.

Alexandre Porcello, Kelly Lourenço, Cíntia Marques, Wassim Raffoul, Marco Cerrano, Lee Ann Applegate, Alexis E Laurent

Abstract read

In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandre PorcelloDevelopment Department, LOUNA REGENERATIVE SA, CH-1228 Plan-les-Ouates, Switzerland.ORCID 0000-0003-1603-2704

Kelly LourençoDevelopment Department, LOUNA REGENERATIVE SA, CH-1228 Plan-les-Ouates, Switzerland.

Cíntia MarquesDevelopment Department, LOUNA REGENERATIVE SA, CH-1228 Plan-les-Ouates, Switzerland.ORCID 0000-0003-3375-6720

Wassim RaffoulPlastic and Reconstructive Surgery, Ensemble Hospitalier de la Côte, CH-1110 Morges, Switzerland.ORCID 0009-0005-8916-9463

Marco CerranoEntourage Aesthetic Clinic, CH-1003 Lausanne, Switzerland.ORCID 0009-0006-0093-8826

Lee Ann ApplegateRegenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Epalinges, Switzerland.ORCID 0000-0002-7346-9921

Alexis E LaurentManufacturing Department, LAM Biotechnologies SA, CH-1066 Epalinges, Switzerland.ORCID 0000-0001-5738-8702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the safety and effectiveness of HYDRAGEL A2, an injectable medical device containing hyaluronic acid (HA), polynucleotides (PN), and niacinamide, for improving facial skin quality. These ingredients are increasingly recognized for their synergistic effects in aesthetic medicine, with HA and PN providing hydration and skin support, and niacinamide offering anti-inflammatory and antioxidant properties. A prospective, open-label clinical investigation was conducted on 42 female subjects (mean age 45 ± 1 years, Fitzpatrick skin phototypes II-V) to assess skin elasticity, hydration, and mild skin depression correction following cheek area injections. Efficacy was measured using the Global Aesthetic Improvement Scale (GAIS), Antera 3D

Indexed as

CutometerDermascanGAIS (Global Aesthetic Improvement Scale)hyaluronic acidniacinamidepolynucleotidesskin elasticityskin hydrationskin qualityskin texture

Identifiers

PMID42188421

DOI10.3390/jfb17050254

PMCPMC13208250

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.