Evidence map›Paper›PMID 42188417›Full record

ArticleJournal of functional biomaterials2026

Molecular Insights into the Synergistic Effect of Nano-Hydroxyapatite and

Ana Carolina Loyola Barbosa, José Augusto Gabarra Júnior, Lilian Eslaine Costa Mendes da Silva, Fernando Nóbrega, Edmara Tatiely Pedroso Bergamo, Bruna Ghiraldini, Roberto Sales E Pessoa, Michel Reis Messora, Sergio Scombatti de Souza

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana Carolina Loyola BarbosaSchool of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-904, SP, Brazil.ORCID 0000-0001-8711-6791
José Augusto Gabarra JúniorSchool of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-904, SP, Brazil.
Lilian Eslaine Costa Mendes da SilvaRibeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.ORCID 0000-0002-1673-264X
Fernando NóbregaSchool of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-904, SP, Brazil.ORCID 0000-0002-0121-0996
Edmara Tatiely Pedroso BergamoDepartment of Biomaterials and Biomimetics, New York University, New York, NY 10010, USA.
Bruna GhiraldiniResearch & Development Department, S.I.N. Implant System, São Paulo 03033-021, SP, Brazil.ORCID 0000-0002-3693-3035
Roberto Sales E PessoaResearch & Development Department, S.I.N. Implant System, São Paulo 03033-021, SP, Brazil.ORCID 0000-0003-1763-3691
Michel Reis MessoraSchool of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-904, SP, Brazil.ORCID 0000-0001-8485-9645
Sergio Scombatti de SouzaSchool of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-904, SP, Brazil.ORCID 0000-0002-6199-7348

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/04468-3
6 · The paper itself

Abstract

Poor bone quality in osteoporotic patients remains a major challenge for achieving predictable osseointegration. This study serves as a mechanistic complement to previously reported structural data, aiming to investigate the molecular pathways underlying the synergy between nanostructured surfaces and autologous blood concentrates in compromised bone. Ninety-six Wistar rats were divided into healthy (SHAM) and osteoporotic (OVX) groups. Implants with nanostructured hydroxyapatite (NanoHA) or dual acid-etched (DAE) surfaces were installed in the tibiae, associated or not with leukocyte- and platelet-rich fibrin (

Indexed as

gene expressionL-PRFmolecular rescuenano-hydroxyapatiteosseointegrationosteoporosis

Identifiers

PMID42188417
PMCPMC13207991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.