Evidence map›Paper›PMID 42188316›Full record

ArticleMarine drugs2026

Receptor Binding, Functional Activity, and Cell Viability Assessment of Novel Marine-Based Hybrid Peptides from

Marta Bauer, Łukasz Szeleszczuk, Bharath Kumar Velmurugan, Shang-Lun Chiang, Anna K Laskowska, Dariusz M Pisklak, Edina Szűcs, Dávid Gombos, Wojciech Kamysz, Tamás Fehér and 3 more

Abstract read
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In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marta BauerDepartment of Analytical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, 80-416 Gdansk, Poland.
Łukasz SzeleszczukChair and Department of Physical Pharmacy and Bioanalysis, Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 02-093 Warsaw, Poland.ORCID 0000-0002-5302-3797
Bharath Kumar VelmuruganMaitocon Laboratory, Tirupur 641604, India.ORCID 0000-0002-4786-9913
Shang-Lun ChiangDepartment of Medical Laboratory Science, College of Medical Science and Technology, I-Shou University, Kaohsiung 824005, Taiwan.
Anna K LaskowskaDepartment of Pharmaceutical Microbiology, Medical University of Warsaw, 02-106 Warsaw, Poland.
Dariusz M PisklakChair and Department of Physical Pharmacy and Bioanalysis, Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 02-093 Warsaw, Poland.ORCID 0000-0002-4648-9513
Edina SzűcsInstitute of Biochemistry, HUN-REN Biological Research Centre, Temesvári Krt. 62, H-6726 Szeged, Hungary.
Dávid GombosInstitute of Biochemistry, HUN-REN Biological Research Centre, Temesvári Krt. 62, H-6726 Szeged, Hungary.ORCID 0009-0001-9435-6002
Wojciech KamyszDepartment of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, 80-416 Gdansk, Poland.ORCID 0000-0001-5335-3043
Tamás FehérInstitute of Biochemistry, HUN-REN Biological Research Centre, Temesvári Krt. 62, H-6726 Szeged, Hungary.
Natalia PielaszkiewiczMaria Sklodowska-Curie Medical Academy in Warsaw, 03-411 Warsaw, Poland.
Krystian MałekDepartment of Biomedical Research, National Medicines Institute, 00-725 Warsaw, Poland.
Patrycja KleczkowskaMaria Sklodowska-Curie Medical Academy in Warsaw, 03-411 Warsaw, Poland.ORCID 0000-0002-8389-0920

Funding

Medical University of Gdansk Excellence Initiative - Research University 71-01427
6 · The paper itself

Abstract

The hybrid approach remains a compelling strategy for designing molecules that combine enhanced biological activity with a favorable safety profile. Marine peptides, in particular, have attracted significant attention due to their well-documented broad spectrum of biological activities. Peptides derived from rays have been recognized for their diverse biological activities. Notably, physicochemical properties of these peptides support practical application without requiring further refinement of the mature molecule or specialized formulations. In this study, we present two new chimeric peptides, PK01# and PK02#, which incorporate an opioid pharmacophore linked to a short amino acid sequence derived from the skate

Indexed as

Antineoplastic AgentsPeptidesReceptors, Opioid, muAnimalsAquatic OrganismsCell Line, TumorCell SurvivalErbB ReceptorsHeLa CellsHumansMolecular Docking SimulationPharmacophoreAntineoplastic AgentsErbB ReceptorsPeptidesReceptors, Opioid, mucytotoxicityefficacyhybrid peptidemarine peptidesmolecular target

Identifiers

PMID42188316
PMCPMC13208969

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.