Evidence map›Paper›PMID 42188286›Full record

ArticleMarine drugs2026

From Sea to Therapy: Development and Analytical Control of Recombinant Human CDKL5 Production in the Marine Bacterium

Andrea Coletti, Marzia Calvanese, Flora Cozzolino, Ilaria Iacobucci, Concetta Lauro, Angelica Severino, Maria Monti, Ermenegilda Parrilli, Maria Luisa Tutino

Abstract read
In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrea ColettiDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.ORCID 0009-0003-4318-8947
Marzia CalvaneseDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.ORCID 0000-0002-7554-0680
Flora CozzolinoDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.ORCID 0000-0002-4648-8107
Ilaria IacobucciDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.ORCID 0000-0001-6210-5607
Concetta LauroDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.ORCID 0000-0003-0139-5166
Angelica SeverinoDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.ORCID 0000-0002-1131-6954
Maria MontiDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.ORCID 0000-0002-7775-7154
Ermenegilda ParrilliDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.ORCID 0000-0002-9002-5409
Maria Luisa TutinoDepartment of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy.ORCID 0000-0002-4978-6839

Funding

Italian Ministry of University and Research (MUR) 2022J5X82RRegione Campania (Fondo di Rotazione ex L. 183/1987- Avvio delle misure organizzative per la "Promozione di progetti di ricerca, sviluppo sperimentale e innovazione collaborativi nel campo delle malattie rare") 26the National Center 5 "National Biodiversity Future Center" CN00000033University of Pennsylvania Orphan Disease Cente CDKL5-23-103-1
6 · The paper itself

Abstract

Marine bacteria are increasingly explored as alternative microbial platforms for the production of high-value biopharmaceuticals. In this study, we investigate the Antarctic marine bacterium

Indexed as

Protein Serine-Threonine KinasesPseudoalteromonasRecombinant ProteinsAquatic OrganismsEnzyme-Linked Immunosorbent AssayHumansPhosphorylationCDKL5 protein, humanProtein Serine-Threonine KinasesRecombinant ProteinsAntarctic marine bacteriacell factorydifficult to express proteinsELISAhCDKL5protein phosphorylationPseudoalteromonas haloplanktis TAC125quality by design

Identifiers

PMID42188286
PMCPMC13208570

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.