Evidence map›Paper›PMID 42188250›Full record

ArticleJournal of imaging2026

MRI-Derived Biomarkers and Radiomic Signatures for Early, Dose-Dependent Evaluation of Prostate Cancer Radiotherapy: An Exploratory Study.

Eleni Bekou, Admir Mulita, Ioannis M Koukourakis, Nikolaos Courcoutsakis, Athanasia Kotini, Evlampia Psatha, Georgios Tsakaldimis, Ioannis Seimenis, Michael I Koukourakis, Efstratios Karavasilis

Abstract read
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In one paragraph

Article in Journal of imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eleni BekouMedical Physics Laboratory, School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0009-0002-1290-1802
Admir MulitaDepartment of Radiotherapy/Oncology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0009-0003-0331-5008
Ioannis M KoukourakisDepartment of Clinical Radiation Oncology, School of Medicine, Attikon Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Nikolaos CourcoutsakisDepartment of Radiology, School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Athanasia KotiniMedical Physics Laboratory, School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-0575-8243
Evlampia PsathaDepartment of Radiology, School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Georgios TsakaldimisDepartment of Urology, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-4831-870X
Ioannis SeimenisMedical Physics Laboratory, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-3665-5271
Michael I KoukourakisDepartment of Radiotherapy/Oncology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-2324-699X
Efstratios KaravasilisMedical Physics Laboratory, School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study provides an accurate assessment of radiotherapy-induced tissue changes in prostate cancer when relying solely on serum prostate-specific antigen kinetics. The current study aims to explore the role of quantitative magnetic resonance imaging and radiomic analyses. In this exploratory prospective study, 22 patients with histologically confirmed prostate cancer underwent multiparametric magnetic resonance imaging at three time points: pre-treatment, mid-treatment, and two months post-radiotherapy. Quantitative imaging analysis included total prostate volume, T2, apparent diffusion coefficient-ADC, and T2* mapping, alongside T2-weighted and diffusion-weighted radiomic feature extraction. Longitudinal changes and dose correlations were analyzed using repeated-measures ANOVA and linear mixed-effects models. Prostate volume increased from 44.22 ± 21.26 cm

Indexed as

dose-dependent imagingmagnetic resonance imagingMRI biomarkersprostate cancerradiomicsradiotherapytreatment response evaluation

Identifiers

PMID42188250
PMCPMC13207975

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.