Evidence map›Paper›PMID 42188120›Full record

ArticleInsects2026

Methodological Evaluation of a P2C-Based ReMOT CRISPR/Cas9 System in

Xiaohui Liu, Wenhao Wang, Xiaoxue Xie, Haotian Yu, Chunxiao Li

Abstract read
In one paragraph

Article in Insects, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaohui LiuState Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.
Wenhao WangState Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.
Xiaoxue XieState Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.
Haotian YuState Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.ORCID 0000-0002-4944-5743
Chunxiao LiState Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.

Funding

National Key Technology R&D Program of China 2024YFC2607800
6 · The paper itself

Abstract

Mosquito-borne infectious diseases remain a major challenge to public health, highlighting the need for efficient and accessible gene editing approaches. Receptor-mediated ovary transduction of cargo (ReMOT) offers an alternative to embryonic microinjection, in which P2C, an ovary-targeting peptide, enables ovarian delivery of the editing components. However, key design parameters and operational boundaries of the P2C-based ReMOT system have not been clearly defined. Here, we performed a methodological evaluation of the P2C-mediated ReMOT CRISPR/Cas9 system in

Indexed as

Aedes aegyptiCRISPR/Cas9gene editingReMOT

Identifiers

PMID42188120
PMCPMC13207695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.