ArticleJournal of cardiovascular development and disease2026
The Correlation Between Plasma CACNA2D1 Protein Concentration and the Severity of Coronary Heart Disease.
Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe prevalence of coronary heart disease (CHD) continues to rise, and there is a lack of methods for early detection. To identify biomarkers for CHD, we analyzed the CACNA2D1 protein concentration in patients with different degrees of coronary artery stenosis to explore the correlation between plasma CACNA2D1 protein concentration and the severity of coronary artery stenosis.
methodsA total of 267 inpatients from the Department of Cardiology at Dalian Central Hospital who underwent coronary angiography were consecutively enrolled. According to the degree of stenosis, they were divided into four groups: minimal stenosis (70 cases), mild stenosis (68 cases), moderate stenosis (66 cases), and severe stenosis (63 cases). The baseline characteristics, clinical laboratory indicators, and CACNA2D1 protein concentration in blood samples of patients in each group were compared, and the correlations were analyzed.
resultsAs the degree of coronary artery stenosis worsened, plasma CACNA2D1 protein concentration in patients showed a gradual upward trend. The protein concentration was lowest in the mild stenosis group, at 37.68 ng/mL; it was 45.46 ng/mL in the mild-to-moderate stenosis group; it reached 55.22 ng/mL in the moderate stenosis group; and it was highest in the severe stenosis group, at 79.95 ng/mL.
conclusionThere is a correlation between plasma CACNA2D1 protein concentration and the degree of coronary artery stenosis, demonstrating that it has the potential to serve as a biomarker.
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