Evidence map›Paper›PMID 42188037›Full record

ArticleMetabolites2026

Exploratory Associations of Inflammatory Cytokines, Brain-Derived Neurotrophic Factor, and Vascular Endothelial Growth Factor with Clinical Outcomes in Patients with Bipolar Disorder.

Fumito Hamada, Leo Gotoh, Yuko Tomiyama, Hiroko Sugawara, Muneaki Ogata, Hiroki Kumagai, Ryo Asada, Ryusei Hatae, Kiyohiro Yasumatsu, Hikaru Hori

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fumito HamadaDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jyonan-ku, Fukuoka City 8140180, Fukuoka, Japan.
Leo GotohDepartment of Psychiatry, Shiranui Hospital, Tegama, Omuta City 8360004, Fukuoka, Japan.
Yuko TomiyamaDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jyonan-ku, Fukuoka City 8140180, Fukuoka, Japan.
Hiroko SugawaraDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jyonan-ku, Fukuoka City 8140180, Fukuoka, Japan.ORCID 0000-0001-5479-6161
Muneaki OgataDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jyonan-ku, Fukuoka City 8140180, Fukuoka, Japan.
Hiroki KumagaiDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jyonan-ku, Fukuoka City 8140180, Fukuoka, Japan.
Ryo AsadaDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jyonan-ku, Fukuoka City 8140180, Fukuoka, Japan.ORCID 0000-0001-8774-048X
Ryusei HataeDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jyonan-ku, Fukuoka City 8140180, Fukuoka, Japan.
Kiyohiro YasumatsuDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jyonan-ku, Fukuoka City 8140180, Fukuoka, Japan.
Hikaru HoriDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jyonan-ku, Fukuoka City 8140180, Fukuoka, Japan.ORCID 0000-0001-8179-3054

Funding

Clinical Research Promotion Foundation 2022
6 · The paper itself

Abstract

BACKGROUND/

objectivesBipolar disorder is characterized by psychosocial dysfunction, cognitive impairment, and incomplete recovery. Although inflammatory and neurotrophic mechanisms have been implicated, their relationships with multidimensional recovery outcomes remain unclear. We examined the relationships of inflammatory cytokines, brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) with depressive symptoms, psychosocial functioning, cognitive performance, personal recovery, and quality of life (QOL) in patients with bipolar disorder.

methodsThis cross-sectional study of 24 patients with bipolar disorder assessed depressive symptoms, psychosocial functioning, cognitive functions, personal recovery, and QOL. Plasma tumor necrosis factor alpha, interleukin (IL)-6, IL-1β, IL-2, BDNF, and VEGF-A were measured by assay.

resultsSubjective cognitive dysfunction was significantly associated with depressive symptom severity (rho = 0.53,

conclusionsThis pilot study suggests that there may be associations between cognitive impairment and cytokines, as well as between quality of life and VEGF, in bipolar disorder. Further studies with larger sample sizes are needed.

Indexed as

bipolar disorderbrain-derived neurotrophic factorcytokinesvascular endothelial growth factor

Identifiers

PMID42188037
PMCPMC13208748

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.