Evidence map›Paper›PMID 42187735›Full record

ArticleBiology2026

Association Between Multiple Sclerosis Severity and Functional Variants in Key Antioxidant Defense and Ferroptosis-Related Genes.

Tamara Djuric, Jovana Kuveljic, Ana Djordjevic, Milan Stefanovic, Evica Dincic, Mariana Seke, Aleksandra Stankovic, Maja Zivkovic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tamara DjuricLaboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-9857-9828
Jovana KuveljicLaboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-6109-9460
Ana DjordjevicLaboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-0316-8461
Milan StefanovicLaboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-4272-2370
Evica DincicClinic for Neurology, Military Medical Academy, 11000 Belgrade, Serbia.ORCID 0009-0007-2945-6561
Mariana SekeLaboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-8024-2832
Aleksandra StankovicLaboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-1050-5913
Maja ZivkovicLaboratory for Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-0447-6626

Funding

Ministry of Science, Technological Development and Innovation Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-33/2026-03/ 200017Science Fund of the Republic of Serbia 7753406
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic, progressive, inflammatory neurodegenerative disease. Oxidative stress and ferroptosis are implicated in MS pathology, contributing to both inflammation and neurodegeneration. Potentially functional variants in genes related to antioxidant defense and ferroptosis were chosen through an extensive selection process to investigate their possible association with the progressive form of MS. The study included 845 MS patients (604 relapsing-remitting (RRMS) and 241 progressive (PMS)). The selected gene variants-

Indexed as

ferroptosisgene variantsmRNA expressionMS severitymultiple sclerosisoxidative stress

Identifiers

PMID42187735
PMCPMC13203362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.