ArticleBiosensors2026
An LSPR-Active AuNP-Silicone Hydrogel Contact Lens for Continuous Ocular Strain Sensing: From Engineering Design to In Vivo Validation.
Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Continuous intraocular pressure (IOP) monitoring is crucial for glaucoma management. Currently, traditional static IOP measurements often fail to detect circadian fluctuations, leading to a clinical dilemma where "normal IOP" is observed despite persistent visual field deterioration. This study presents a wireless, passive localized surface plasmon resonance (LSPR) sensing platform integrated into flexible silicone hydrogel contact lenses. Gold nanoparticles (AuNPs), synthesized via the sodium citrate reduction method, were incorporated into the lens periphery using a "swelling-induced nano-doping" technique to transduce IOP-induced corneal strain into detectable spectral shifts. Ex vivo porcine eye investigations established a physical mapping model, confirming significant LSPR peak wavelength response trends in correlation with IOP variations (10-50 mmHg) and corneal curvature changes. Subsequent 21-day in vivo rabbit studies demonstrated excellent ocular surface biocompatibility; quantitative histopathological analysis (HE, PAS, and Ki67 staining) revealed no significant adverse alterations in corneal endothelial cell density or conjunctival goblet cell function compared to control groups (
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