Evidence map›Paper›PMID 42187467›Full record

ArticleBiosensors2026

Fabrication of Co-Doped Covalent Organic Framework Nanosheets with Mild Interlayer Stress for Quantitative Detection of Alzheimer's Disease Biomarkers.

Yubing Lv, Yanli Zhou, Zi Liu, Hui Dong, Hejie Zheng, Sihan Cheng, Xu Wang, Chaoran Lv, Maotian Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yubing LvHenan Key Laboratory of Biomarker Detection and Diagnosis for Neurodegenerative Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
Yanli ZhouHenan Key Laboratory of Biomarker Detection and Diagnosis for Neurodegenerative Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
Zi LiuHenan Key Laboratory of Biomarker Detection and Diagnosis for Neurodegenerative Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
Hui DongHenan Key Laboratory of Biomarker Detection and Diagnosis for Neurodegenerative Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
Hejie ZhengHenan Key Laboratory of Biomarker Detection and Diagnosis for Neurodegenerative Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
Sihan ChengHenan Key Laboratory of Biomarker Detection and Diagnosis for Neurodegenerative Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
Xu WangHenan Key Laboratory of Biomarker Detection and Diagnosis for Neurodegenerative Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.
Chaoran LvDepartment of Hematology, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, China.
Maotian XuHenan Key Laboratory of Biomarker Detection and Diagnosis for Neurodegenerative Diseases, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.

Funding

Henan Academy of Sciences 242300421208National Natural Science Foundation of China 22474072
6 · The paper itself

Abstract

Alzheimer's disease (AD) seriously affects human health worldwide. Nicotinamide adenine dinucleotide (NADH) and glutamate are important biomarkers of AD, which play an indispensable role in the pathogenesis of AD. Herein, two ligands were used to synthesize a layered covalent organic framework (TPCOF) via amide bond formation, which was loaded with cobalt to obtain Co-TPCOF. TPCOF has a twisted 2D layered structure, along with large interlayer spacing and porosity, enabling precise Co coordination and stable loading of metal nanoparticles/enzymes to support electrocatalysis. A Co-TPCOF was immobilized on a screen-printed electrode (SPE) to catalyze the oxidation of NADH. After that, the oxidation product NAD

Indexed as

Alzheimer DiseaseBiosensing TechniquesMetal-Organic FrameworksBiomarkersCobaltElectrochemical TechniquesElectrodesGlutamic AcidHumansMetal NanoparticlesNADNanostructuresBiomarkersCobaltGlutamic AcidMetal-Organic FrameworksNADAD biomarkersco-catalysisCo-TPCOFglutamateNADH

Identifiers

PMID42187467
PMCPMC13204613

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.