Evidence map›Paper›PMID 42187439›Full record

ArticleBiosensors2026

Development of an Electrochemical Platform Based on Zinc Oxide Nanoparticles Embedded onto Montmorillonite Clay Functionalized with Phenylalanine for the Nano-Sensing of Acetaminophen in Pharmaceutical Tablets.

Gildas Calice Wabo, Alex Vincent Somba, Sengor Gabou Fogang, Cyrille Ghislain Fotsop, Astree Lottie Djuffo Yemene, Léopoldine Sonfack Guenang, Marcel Cédric Deussi Ngaha, Gullit Deffo, Evangeline Njanja

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gildas Calice WaboElectrochemistry and Chemistry of Materials, Department of Chemistry, Faculty of Sciences, University of Dschang, Dschang P.O. Box 67, Cameroon.ORCID 0009-0009-4463-501X
Alex Vincent SombaElectrochemistry and Chemistry of Materials, Department of Chemistry, Faculty of Sciences, University of Dschang, Dschang P.O. Box 67, Cameroon.ORCID 0000-0002-9083-8047
Sengor Gabou FogangElectrochemistry and Chemistry of Materials, Department of Chemistry, Faculty of Sciences, University of Dschang, Dschang P.O. Box 67, Cameroon.ORCID 0000-0002-2620-8235
Cyrille Ghislain FotsopInstitute of Chemistry, Faculty of Process and Systems Engineering, Universität Platz 2, 39106 Magdeburg, Germany.ORCID 0000-0001-6455-2515
Astree Lottie Djuffo YemeneElectrochemistry and Chemistry of Materials, Department of Chemistry, Faculty of Sciences, University of Dschang, Dschang P.O. Box 67, Cameroon.ORCID 0009-0000-0362-2313
Léopoldine Sonfack GuenangElectrochemistry and Chemistry of Materials, Department of Chemistry, Faculty of Sciences, University of Dschang, Dschang P.O. Box 67, Cameroon.ORCID 0009-0004-7398-7245
Marcel Cédric Deussi NgahaDepartment of Chemistry, Higher Teacher Training College, The University of Bamenda, Bamenda P.O. Box 39, Cameroon.ORCID 0000-0002-3024-9507
Gullit DeffoElectrochemistry and Chemistry of Materials, Department of Chemistry, Faculty of Sciences, University of Dschang, Dschang P.O. Box 67, Cameroon.ORCID 0000-0002-4399-4821
Evangeline NjanjaElectrochemistry and Chemistry of Materials, Department of Chemistry, Faculty of Sciences, University of Dschang, Dschang P.O. Box 67, Cameroon.ORCID 0000-0003-4782-6232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study describes the development of an electrochemical sensor for quantitatively measuring acetaminophen (ACOP) in drug tablets. The sensor design is based on the modification of glassy carbon electrode (GCE) using zinc oxide nanoparticles (ZnONPs) embedded in a naturally occurring clay matrix (Sa) functionalized with phenylalanine (Phe). To ensure that the ZnONPs are homogeneously dispersed on the clay surface, the nanocomposite was synthesized using an impregnation approach and low-temperature heat treatment. The amino acid promotes specific interactions with ACOP through hydrogen bonding and π-π stacking, acting as both a stabilizing agent and a molecular recognition moiety. FTIR, UV-Vis, XRD, and FESEM/EDX mapping were employed to fully characterize the developed material (ZnONPs-Sa/Phe). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used for the electrochemical determination of ACOP using the modified electrode GCE/ZnONPs-Sa/Phe. Parameters susceptible to affecting the sensitivity of the developed sensor were optimized, revealing that 5 µL of the suspension ZnONPs-Sa/Phe immobilized on GCE was ideal for the sensing of ACOP in a phosphate buffer solution at pH 2.0. The calibration curve obtained by plotting peak current intensity against ACOP concentration exhibited linear behavior within the concentration range between 0.02 µM and 0.28 µM, enabling determination of the limits of detection (LOD) and quantitation (LOQ) at 8.54 × 10

Indexed as

AcetaminophenBiosensing TechniquesElectrochemical TechniquesBentoniteClayElectrodesLimit of DetectionNanocompositesNanoparticlesPhenylalanineTabletsZinc OxideAcetaminophenBentoniteClayPhenylalanineTabletsZinc Oxideacetaminophenelectrochemical sensormontmorillonite clayphenylalanineZnO nanoparticles

Identifiers

PMID42187439
PMCPMC13204949

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.