Evidence map›Paper›PMID 42187194›Full record

ReviewBJPsych open2026

Prevalence of mental disorders in people with intellectual disabilities across the lifespan: umbrella review.

Jacopo Santambrogio, Giovanni Boido, Mattia Marchetti, Sonya Rudra, Filippo Besana, Emma Francia, Sergio Terrevazzi, Davide Papola, Corrado Barbui, Marco Bertelli and 4 more

Abstract readReview
In one paragraph

Review in BJPsych open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jacopo SantambrogioDisability Unit, Department of Mental Health and Addiction, ASST Brianza, Vimercate, Italy.ORCID https://orcid.org/0000-0001-7668-7564
Giovanni BoidoDepartment of Health Studies, University of Milanhttps://ror.org/00wjc7c48, Milan, Italy.ORCID https://orcid.org/0009-0008-8427-9614
Mattia MarchettiDepartment of Health Studies, University of Milanhttps://ror.org/00wjc7c48, Milan, Italy.
Sonya RudraDivision of Psychiatry, University College Londonhttps://ror.org/02jx3x895, London, UK.
Filippo BesanaDepartment of Mental Health and Addiction, ASST Santi Paolo e Carlohttps://ror.org/03dpchx26, Milan, Italy.
Emma FranciaIndependent Scholar, Milan, Italy.
Sergio TerrevazziDisability Unit, Department of Mental Health and Addiction, ASST Brianza, Vimercate, Italy.
Davide PapolaWHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0001-6482-8593
Corrado BarbuiWHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0003-1073-9282
Marco BertelliCREA (Clinical and Research Centre), San Sebastiano Foundation, Misericordia di Firenze, Florence, Italy.ORCID https://orcid.org/0000-0002-4228-9338
Massimo ClericiFormer Professor of Psychiatry, School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Armando D'AgostinoDepartment of Health Studies, University of Milanhttps://ror.org/00wjc7c48, Milan, Italy.ORCID https://orcid.org/0000-0002-2126-799X
Louise MarstonDivision of Psychiatry, University College Londonhttps://ror.org/02jx3x895, London, UK.ORCID https://orcid.org/0000-0002-9973-1131
Angela HassiotisDivision of Psychiatry, University College Londonhttps://ror.org/02jx3x895, London, UK.ORCID https://orcid.org/0000-0002-9800-3909

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeople with intellectual disabilities experience higher rates of mental disorders, contributing to restrictive practices and premature mortality. Prevalence data are essential to understanding the patterns of disease, and for the development of tailored interventions.

aimsTo systematically examine the burden and pattern of mental disorders in people with intellectual disabilities across the lifespan.

methodWe searched six databases (inception to 17 October 2024), and conducted a manual search up to 15 December 2024, for systematic reviews on the prevalence of mental disorders in people with intellectual disabilities with or without neurodevelopmental conditions. We conducted a narrative synthesis of prevalence rates, including those stratified by intellectual disability level, sex, age and autism, where available, and compared these with published prevalence rates in people without intellectual disabilities (International Prospective Register of Systematic Reviews, no. CRD42024610611).

resultsWe included 26 systematic reviews: 7 meta-analyses and 19 narrative reviews. Compared with the general population, the prevalence of schizophrenia (3.55-4.80%), anxiety (5.4-5.5%) and obsessive-compulsive disorders (2.4%) appeared higher, whereas that of mood (6-7%), personality and post-traumatic stress disorders appeared lower. Study quality was moderate to critically low. For syndromic intellectual disabilities we noted high anxiety rates in fragile-X, Williams and 22q11.2 deletion syndromes, and in those with co-occurring autism. We found gaps on dementia, bipolar, substance use and eating disorders, and limited data stratified by intellectual disability level, sex and age.

conclusionsThis umbrella review confirms the high prevalence of mental disorders among people with intellectual disabilities, and highlights limited evidence for several conditions and population subgroups, including for minoritised ethnic groups. Standardised, high-quality epidemiological research is needed to shape clinical care and public mental health policy.

Indexed as

comorbiditydiagnosis and classificationepidemiologyIntellectual disabilitysystematic review

Identifiers

PMID42187194
PMCPMC13227151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.