Evidence map›Paper›PMID 42187116›Full record

ArticlePhysical chemistry chemical physics : PCCP2026

Identifying potential binding sites for complex formation between Tyrosyl-DNA phosphodiesterase 1 and poly [ADP-ribose] polymerase 1.

Sophia Wang, Aykut Üren, Purushottam B Tiwari

Abstract read
In one paragraph

Article in Physical chemistry chemical physics : PCCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sophia WangDepartment of Biology, Georgetown University, Washington, D.C. 20057, USA.ORCID http://orcid.org/0009-0002-7704-9905
Aykut ÜrenDepartment of Oncology, Georgetown University, Washington, D.C. 20057, USA. pbt7@georgetown.edu.ORCID http://orcid.org/0000-0002-2033-1216
Purushottam B TiwariDepartment of Oncology, Georgetown University, Washington, D.C. 20057, USA. pbt7@georgetown.edu.ORCID http://orcid.org/0000-0002-3140-0723

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
NCI NIH HHS P30 CA051008
6 · The paper itself

Abstract

DNA topoisomerases manage the supercoiled structure of the genomic DNA through breaking and rejoining DNA strands, which is a key step in many cellular processes. DNA topoisomerase I (TOPI) forms TOPI-DNA cleavage complex (TOPIcc)

Indexed as

Phosphoric Diester HydrolasesPoly (ADP-Ribose) Polymerase-1Binding SitesDNADNA Topoisomerases, Type IHumansMolecular Dynamics SimulationProtein BindingDNADNA Topoisomerases, Type IPARP1 protein, humanPhosphoric Diester HydrolasesPoly (ADP-Ribose) Polymerase-1TDP1 protein, human

Identifiers

PMID42187116
PMCPMC13203358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.