Evidence map›Paper›PMID 42187004›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Ultrasensitive Detection of Neurofilament Light in Plasma Using F(Ab')

Selvinaz Burcu Kizilates, Rica Asrosa, Lenart Senicar, Anuja Sharma, Seda Gungordu Er, Nisha Naeem, Ahmad Nizamuddin Bin Muhammad Mustafa, Yang Wu, Neil Graham, Amanda Heslegrave and 7 more

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In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Selvinaz Burcu KizilatesInstitute For Materials Discovery, University College London, London, UK.
Rica AsrosaInstitute For Materials Discovery, University College London, London, UK.
Lenart SenicarInstitute For Materials Discovery, University College London, London, UK.
Anuja SharmaInstitute For Materials Discovery, University College London, London, UK.
Seda Gungordu ErDepartment of Mechanical Engineering, University College London, London, UK.
Nisha NaeemDepartment of Electronic and Electrical Engineering, University College London, London, UK.
Ahmad Nizamuddin Bin Muhammad MustafaDepartment of Materials, Imperial College London, London, UK.
Yang WuElectrical Engineering Division, University of Cambridge, Cambridge, UK.
Neil GrahamDepartment of Brain Sciences, Imperial College London, London, UK.
Amanda HeslegraveUK Dementia Research Institute, University College London, London, UK.
Mohan EdirisingheDepartment of Mechanical Engineering, University College London, London, UK.
Antonio LombardoDepartment of Electronic and Electrical Engineering, University College London, London, UK.
Elias TorresGraphenea Semiconductor, San Sebastián, Spain.
Henrik ZetterbergUK Dementia Research Institute, University College London, London, UK.
Sami RamadanInstitute For Materials Discovery, University College London, London, UK.
David J SharpDepartment of Brain Sciences, Imperial College London, London, UK.
Bing LiInstitute For Materials Discovery, University College London, London, UK.

Funding

AD Strategic Fund and the Alzheimer's Association ADSF-21-831376-CAD Strategic Fund and the Alzheimer's Association ADSF-21-831377-CAD Strategic Fund and the Alzheimer's Association ADSF-21-831381-CAD Strategic Fund and the Alzheimer's Association ADSF-24-1284328-CAlzheimer Drug Discovery Foundation #201809-2016862Alzheimer's Society 659Bluefield ProjectCure Alzheimer's FundEngineering and Physical Sciences Research Council EP/X525649/1Erling-Persson Family FoundationEuropean Union Joint Programme-Neurodegenerative Disease Research JPND2021-00694European Union's Horizon 2020 research and innovation programme 860197European Union's Horizon Europe research and innovation programme 101053962Familjen Rönströms StiftelseIndonesia Endowment Fund for Education 202112222808254Medical Research Council MR/X502984/1Ministry of National Education of TürkiyeNIHR Professorship NIHR-RP-011-048Olav Thon FoundationRosetrees Trust Seedcorn2023∖100182Royal Society IEC∖NSFC∖223128Royal Society RG∖R1∖241087Stiftelsen för Gamla Tjänarinnor FO2022-0270Swedish Research Council 2019-02397Swedish Research Council 2022-01018Swedish Research Council 2023-00356Swedish State Support for Clinical Research ALFGBG-71320UK Dementia Research Institute at UCL UKDRI-1003
6 · The paper itself

Abstract

Neurofilament light (NfL) is a discriminative blood biomarker for many neurological diseases. Current accurate analysis relating to NfL relies on state-of-the-art technologies such as the single-molecule array (Simoa) and immunoprecipitation-mass spectrometry (IP-MS), which require complicated machinery, skilled operational personnel, and well-equipped laboratories. Herein, we demonstrate a robust on-chip graphene field-effect transistor (GFET) biosensing platform for the ultrasensitive detection of NfL. This work utilizes smaller antibody fragments F(ab')

Indexed as

Biosensing TechniquesGraphiteNeurofilament ProteinsHumansLimit of DetectionSuccinimidesTransistors, ElectronicGraphiteNeurofilament ProteinsN-hydroxysuccinimideSuccinimides1‐Pyrenebutyric acid N‐hydroxysuccinimide esterbiosensorsDebye lengthF(ab’)2 antibody fragmentationgraphene field‐effect transistors

Identifiers

PMID42187004
PMCPMC13360647

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.