Observational studyESC heart failure2026
Adipokine profile in acute heart failure: associations with natriuretic response and prognosis.
Observational study in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of heart failure pharmacotherapy on natriuresis and diuresis: A narrative review.Heart failure reviews · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
introductionAdipose tissue signalling is linked to heart failure (HF), but its role in acute HF (AHF), especially concerning early diuretic response, is unclear. Early natriuretic response to loop diuretics is vital for effective decongestion.The objective was to characterize and evaluate the associations between circulating adipokine profiles, early natriuretic response, and clinical outcomes in AHF.
methodsWe conducted a prospective observational study including 262 consecutive AHF patients. Early diuretic response was assessed by measuring post-diuretic spot urine sodium (uNa+) 2 h after intravenous loop diuretic administration. Associations between adipokines and uNa+ were assessed, and an adipokine score was constructed based on markers associated with uNa+. Clinical outcomes (all-cause mortality and a composite of death or HF hospitalization) were evaluated over 1 year using Cox regression models.
resultsPatients with impaired natriuretic response (uNa+ < 90 mmol/L) exhibited higher levels of selected Domain-3 adipokines, including chemerin and FABP4. Individual adipokines showed modest associations with early natriuretic response. Visfatin was significantly associated with lower post-diuretic uNa+, while IL-6, FABP4, and Adipsin demonstrated directional but non-significant trends. An adipokine score integrating these selected adipokines was independently associated with uNa+ after multivariable adjustment (β 3.37, 95% CI 1.51-5.23; P < .001). During a 1-year follow-up, several adipokines: IL-6, resistin, and FABP4, were independently associated with mortality, while FABP4 consistently demonstrated associations with both impaired natriuresis and adverse outcomes.
conclusionsIn AHF, individual adipokines are modestly associated with the early natriuretic response, whereas an integrated adipose-inflammatory profile shows a more consistent association with sodium excretion and adverse outcomes. These findings suggest that adipokine signalling may reflect biological pathways associated with diuretic response and prognosis, though the results should be considered hypothesis-generating.
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