Evidence map›Paper›PMID 42186805›Full record

ArticleCirculation research2026

Targeting Arrhythmogenic Late Sodium Current by FHF1

Bence Hegyi, Paweorn Angsutararux, Nourdine Chakouri, Ryan W Mahling, Lucile Fossier, Hai M Nguyen, Shannon Gilhooly, Victor Alencar Almeida, Charlotte E R Smith, Lianguo Wang and 7 more

Abstract read
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Targeting Late NaCirculation research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bence HegyiDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).ORCID 0000-0003-3113-221X
Paweorn AngsutararuxDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).ORCID 0000-0003-1083-5004
Nourdine ChakouriDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY (N.C., R.W.M., L.F., M.B.-J.).ORCID 0000-0002-8809-8684
Ryan W MahlingDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY (N.C., R.W.M., L.F., M.B.-J.).
Lucile FossierDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY (N.C., R.W.M., L.F., M.B.-J.).ORCID 0000-0002-1837-9093
Hai M NguyenDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).ORCID 0000-0002-1422-7041
Shannon GilhoolyDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).
Victor Alencar AlmeidaDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).ORCID 0000-0002-1079-3089
Charlotte E R SmithDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).ORCID 0000-0002-1165-1752
Lianguo WangDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).ORCID 0000-0002-4747-0419
Crystal M RipplingerDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).ORCID 0000-0002-9908-4106
Jody L MartinDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).ORCID 0000-0001-5607-3338
Kenneth S GinsburgDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).
Kenneth C BediCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (K.C.B., K.B.M.).ORCID 0000-0003-3588-9324
Kenneth B MarguliesCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (K.C.B., K.B.M.).ORCID 0000-0002-8093-4465
Manu Ben-JohnyDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY (N.C., R.W.M., L.F., M.B.-J.).ORCID 0000-0002-5645-0815
Donald M BersDepartment of Pharmacology, University of California, Davis (B.H., P.A., H.M.N., S.G., V.A.A., C.E.R.S., L.W., C.M.R., J.L.M., K.S.G., D.M.B.).ORCID 0000-0002-2237-9483

Funding

Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL142282
6 · The paper itself

Abstract

backgroundEnhanced late Na

methodsReverse-transcriptase quantitative polymerase chain reaction analysis of cardiac Na

resultsExpression of key FHF long isoforms (FHF1

conclusionsIn HF, I

Indexed as

Anti-Arrhythmia AgentsArrhythmias, CardiacFibroblast Growth FactorsHeart FailureMuscle ProteinsMyocytes, CardiacSodiumSodium ChannelsAction PotentialsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Disease Models, AnimalHumansMaleMiceMice, TransgenicAnti-Arrhythmia AgentsCalcium-Calmodulin-Dependent Protein Kinase Type 2Fibroblast Growth FactorsMuscle ProteinsSodiumSodium Channelsaction potentialsarrhythmias, cardiacelectrophysiologyheart failuresodium channels

Identifiers

PMID42186805
PMCPMC13215156

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.