Evidence map›Paper›PMID 42186774›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Social connection and cognitive health: A review of concepts, measures, and research priorities.

Reed DeAngelis, Lindsey Burnside, Darby O Donnell, Margaret Hicken, Debra Umberson, Brea Perry

Abstract readReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Reed DeAngelisInstitute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-6471-9802
Lindsey BurnsideInstitute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Darby O DonnellInstitute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Margaret HickenInstitute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Debra UmbersonDepartment of Sociology, University of Texas at Austin, Austin, Texas, USA.
Brea PerryDepartment of Sociology and Irsay Institute, Indiana University, Bloomington, Indiana, USA.

Funding

Gateway Exposome Coordinating Center (GECC) For AD/ADRD ResearchU24AG088894 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, David Michael Keith Knapp · 2024 to 2026
$14.8M
Program Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI KAREN L FINGERMAN · 2020 to 2026
$5.2M
Epigenetic mechanisms underlying the direct and moderating effects of social connectedness on complex diseases in agingR01AG076032 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI Brea Louise Perry · 2022 to 2026
$2.9M
How Spouses Influence Each Other's Health in Same- and Different-Sex Marriages: A Dyadic and Longitudinal Assessment from Mid to Later LifeR37AG076057 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI DEBRA J. UMBERSON · 2022 to 2026
$2.3M
Social Networks in Alzheimer Disease 2.0.R37AG057739 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI PERRY, BREA LOUISE · 2024 to 2025
$1.5M
NIA NIH HHS P30 AG066614NIA NIH HHS P30AG066614NIA NIH HHS R01 AG076032NIA NIH HHS R01AG076032NIA NIH HHS R37 AG057739NIA NIH HHS R37 AG076057NIA NIH HHS R37AG076057NIA NIH HHS R37AG57739NIA NIH HHS U24 AG088894NIA NIH HHS U24AG088894
6 · The paper itself

Abstract

Lack of social connection is a major risk factor for Alzheimer's disease and related dementias, on a par with other common risk factors like physical inactivity and smoking. Yet we still know surprisingly little about how social connection affects cognitive health. Our review provides updated guidance for researchers interested in testing new mechanistic models of social connection and cognitive health over the life course. First, we conceptualize social connection and its various components. Second, we provide readers with a supplemental compendium of social connection measures and discuss how to tailor different types of measures to specific research goals. Third, we advance a conceptual model linking social connection to cognitive health across different social, spatial, and temporal contexts, while also considering potential sources of confounding and reciprocal causation. Finally, we outline five priority areas for future research into social connection and cognitive health across the life course.

Indexed as

CognitionAlzheimer DiseaseHumansAlzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD)cognitive healthlife courselonelinesssocial connectionsocial isolation

Identifiers

PMID42186774
PMCPMC13240448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.