ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2026
Collagen III Deficiency Following Injury in Female Murine Tendons Alters Matrix Composition, Structure, Organization and Function.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tendons withstand large forces due to an aligned, dense collagen matrix. However, their low cellularity and relative inability to recruit reparative cells post-injury, coupled with a susceptibility to excessive scarring results in loss of tendon structure and function. Type III collagen (COL3) plays a key role in regulating matrix architecture and limiting scar formation following cutaneous injury; however, its role in tendon remains unclear. We examined the impact of reduced COL3 using an established murine Col3a1 knockdown model. Uninjured tendons in Col3a1
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