ArticleOrthopedic reviews2026
Suzetrigine for Cancer-Related Bone Pain: A Three-Patient Case Series.
Article in Orthopedic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Cancer-related bone pain remains a clinical challenge, particularly in patients with metastatic disease who have failed conventional pharmacologic therapies. Suzetrigine, a selective NaV1.8 sodium channel inhibitor, is a novel non-opioid analgesic with potential utility in nociceptive and neuropathic pain states. However, its role in advanced cancer-related pain remains unclear. We present a three-patient case series evaluating suzetrigine in patients with metastatic cancer involving the spine. All patients had extensive prior treatment histories, including opioid therapy, and demonstrated no meaningful improvement in pain following a three-week trial of suzetrigine. Treatment was discontinued due to lack of efficacy, and in one case, cost was also a contributing factor. No adverse effects were reported. These findings highlight potential limitations of suzetrigine in advanced cancer-related bone pain, particularly in opioid-tolerant patients.
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