ArticleCureus2026
Discordant Radiologic and Biochemical Response With Inflammatory Activity in Metastatic Prostate Cancer: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Discordance between imaging findings and biochemical markers represents a significant diagnostic and therapeutic challenge in metastatic prostate cancer. We report the case of a 72-year-old male with high-risk prostate adenocarcinoma (Gleason 4+5=9) and extensive bone metastases, who demonstrated partial radiologic and metabolic response on prostate-specific membrane antigen PET/CT and single-photon emission CT/CT imaging following systemic therapy while simultaneously exhibiting rising prostate-specific antigen levels and elevated systemic inflammatory markers. Despite imaging-defined response, CT revealed persistent mixed osteoblastic and osteolytic bone lesions, suggesting underlying biological heterogeneity and asynchronous tumor behavior. This discordant pattern indicates that radiologic improvement may not fully reflect ongoing systemic disease activity. This case supports the hypothesis that systemic inflammatory activity, in conjunction with biochemical progression, may reflect early tumor-host interaction and emerging treatment resistance, potentially preceding overt radiologic progression. These findings underscore the need for integrated, multimodal monitoring strategies combining imaging, biochemical, and inflammatory markers to better capture dynamic disease activity and enable earlier detection of treatment resistance in metastatic prostate cancer.
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