ArticleFrontiers in genetics2026
High prevalence of Hb Q-Thailand not in cis with the -α
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Hb Q-Thailand, a common hemoglobin variation in Southeast Asia, has historically been associated with the -α Methods: A total of 23,546 individuals who underwent capillary electrophoresis screening at our hospital between January 2024 and December 2025 were enrolled in this study. Deletional α-thalassemia mutations were detected using Gap-PCR, while common α-globin chain mutations were identified by PCR-reverse dot blot hybridization (PCR-RDB). Additionally, 17 common β-thalassemia point mutations were analyzed using PCR-RDB. Sanger sequencing was performed to characterize α-globin variants. Results: Thirty-seven positive cases were identified among the 23,546 screened individuals, yielding a positive screening rate of 0.16% (37/23,546) in the Cenxi population. Genetic confirmation was performed in 22 cases, of which 21 were confirmed to carry Hb Q-Thailand, while the remaining case was identified as a rare variant, Hb Zhaoqing. Notably, 10 samples exhibited Hb Q-Thailand without linkage to the -α Conclusion: The Cenxi population presents a high proportion of Hb Q-Thailand cases in which the variant is not linked to the -α
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