ReviewJournal of hypertension2026
A literature review of the pharmacokinetic profiles of 20 commonly prescribed antihypertensive medications for use in chemical adherence testing.
Review in Journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonadherence to antihypertensive medications is a major concern, with significant implications for healthcare systems and patient outcomes. Chemical adherence testing (CAT) is a recommended method to assess nonadherence objectively by detecting drugs or their metabolites in blood or urine samples. Interpretation of CAT results require relevant pharmacokinetic parameters. However, pharmacokinetic data in established sources are not graded for quality and not compiled into a single resource. We systematically collated and graded the literature on pharmacokinetic parameters for 20 commonly prescribed antihypertensive agents. A total of 53 suitable manuscripts were included. Pharmacokinetic data, including half-life and maximum concentration, were collated. Also, minimum concentration at regular dosing intervals was calculated. This resource allows clinicians and researchers to interpret CAT results with more confidence and accuracy and will help facilitate the interpretation of CAT. It also shows that there are significant gaps in available literature, and further research is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.