ArticleAnnals of medicine2026
The association between regional anesthesia and postoperative pulmonary complications following lung resection surgery: a hospital-based, retrospective cohort study.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundRegional anesthesia (RA) are extensively utilized in lung-resection surgery for pain relief. However, the associations between RA and postoperative pulmonary complications (PPCs) remain inconclusive. Therefore, we aimed to investigate the associations between RA and the incidence of PPCs in adults undergoing lung-resection surgery.
methodsThis retrospective cohort study included adult patients who underwent lung-resection surgery under general anesthesia (GA) at a large comprehensive teaching hospital in China. The primary outcome was PPCs within 7 days.
resultsA total of 9,208 patients were enrolled and assigned into group GA, which received GA alone, or group GA+RA, which received GA combined with RA. Within the GA+RA group, patients were further categorized into the GA + PRA group (GA combined with peripheral regional anesthesia) and the GA + EA group (GA combined with epidural anesthesia). Following matching, the GA+RA group showed a non-significant trend toward lower incidence of PPCs (HR 0.93; 95% CI, 0.86-1.01;
conclusionsIn this retrospective cohort study, the addition of RA to GA was not associated with a significantreduction in PPCs within 7 days after lung resection compared to GA alone. Exploratory analyses identified potential subgroup-specific benefits that warrant prospective validation.
trial registrationChinese Clinical Trial Registry (ChiCTR2400090895).
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