ArticleAnnals of medicine2026
Overexpression of SLC44A4 suppresses ferroptosis and reduces lipid peroxidation
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundOvarian cancer (OC) is one of the most common gynecologic malignancies worldwide and is characterized by a high recurrence rate driven by drug resistance, contributing to poor prognosis and increased mortality. Consequently, there is an urgent need to develop novel therapeutic strategies to improve patient outcomes. Although SLC44A4 is known to be highly expressed in various tumor types, its precise functional role and underlying mechanisms in OC remain largely unexplored.
objectiveThis study aims to investigate the effects and underlying mechanisms of SLC44A4 overexpression on the biological behavior of OC cells.
resultsSLC44A4 enhances the proliferation and migration of OC cells both
conclusionOur findings suggest that SLC44A4 overexpression reduces lipid peroxidation and suppresses ferroptosis, with these effects being linked to the activation of noncanonical NF-κB signaling. Thus, SLC44A4 may serve as a potential target for modulating ferroptosis in OC; however, further validation, including loss-of-function studies and patient-derived sample analyses, is required.
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