Evidence map›Paper›PMID 42186272›Full record

ReviewNutrition reviews2026

Cardiometabolic and Microbiome Effects of Spices and Herbs.

Penny M Kris-Etherton, Connie J Rogers, Ester S Oh, Sheila G West, Amandeep K Sandhu, Britt Burton-Freeman, Yudai Huang, David N Proctor, Kristina S Petersen

Abstract readReview
In one paragraph

Review in Nutrition reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Penny M Kris-EthertonDepartment of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, United States.
Connie J RogersDepartment of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, United States.
Ester S OhDepartment of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, United States.
Sheila G WestDepartment of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, United States.
Amandeep K SandhuDepartment of Food Science and Nutrition, Illinois Institute of Technology, Chicago, IL 60616, United States.
Britt Burton-FreemanDepartment of Food Science and Nutrition, Illinois Institute of Technology, Chicago, IL 60616, United States.ORCID 0000-0002-3754-9852
Yudai HuangDepartment of Food Science and Nutrition, Illinois Institute of Technology, Chicago, IL 60616, United States.
David N ProctorDepartment of Kinesiology, Pennsylvania State University, University Park, PA 16802, United States.ORCID 0000-0002-4691-4575
Kristina S PetersenDepartment of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, United States.ORCID 0000-0003-3914-0353

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
McCormick Science InstituteNCATS NIH HHSNIH HHS UL1 TR002014
6 · The paper itself

Abstract

This article appears as part of the supplement "The Role of Spices and Herbs on Supporting Healthy Diets and Improving Nutritional Status," sponsored by the McCormick Science Institute. Studies conducted at Penn State University to evaluate the effects of spices and herbs (S&H) on risk factors for cardiovascular disease (CVD) are summarized herein. We also report effects of S&H on phytochemical metabolites and the microbiome. Results demonstrate beneficial effects of S&H on postprandial endothelial function, insulin and triglycerides, pancreatic lipase, inflammatory markers, and measures of oxidative defense. In a controlled-feeding trial that evaluated 3 doses of S&H (0.5, 3.3, and 6.6 g/d per 2100 kcal) in the context of an average American diet, the high-S&H diet improved 24-hour blood pressure after 4 weeks, the moderate-S&H diet decreased proinflammatory cytokines, and the high-S&H diet reduced monocyte adherence. Our research also identified polyphenol metabolites that may have important functional properties for CVD risk reduction. Finally, we report benefits of S&H on gut bacterial composition, which suggests possible benefits on CVD risk.

Indexed as

Cardiovascular DiseasesGastrointestinal MicrobiomeMicrobiotaSpicesHumansblood pressurecardiovascular disease risk factorsmicrobiomepostprandial responsesspices and herbs

Identifiers

PMID42186272
PMCPMC13201881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.