ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Empathy in primary progressive aphasia: Neural signatures and longitudinal trajectories.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
introductionEmpathy is increasingly recognised as compromised in neurodegenerative disorders. However, its profile and neural bases in the nonfluent (nfvPPA) and logopenic (lvPPA) variants of primary progressive aphasia remain unclear. We aimed to characterize empathy at onset, examine its longitudinal course, and identify neural correlates in nfvPPA and lvPPA.
methodsThirty-four nfvPPA, 38 lvPPA, and 45 control subjects completed neuropsychological and MRI assessment, with follow-up up to 9 years. Empathy was measured using the Interpersonal Reactivity Index (Perspective Taking, Empathic Concern).
resultsAt baseline, both PPA groups showed reduced cognitive empathy but preserved affective empathy. Lower empathy correlated with broader cognitive deficits in nfvPPA and predicted greater caregiver burden. Longitudinally, empathy remained stable in nfvPPA but declined in lvPPA. Brain-behavior analyses implicated temporo-parietal and frontal-insular regions, with progressive frontal atrophy predicting cognitive empathy decline in lvPPA. DISCUSSION: Findings demonstrate early empathy deficits in both variants, distinct trajectories, and syndrome-specific neural substrates, with important clinical implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.