Evidence map›Paper›PMID 42186051›Full record

ReviewMolecular neurodegeneration2026

Neurodegeneration as an evolutionary trade-off: a biological constraint-aware therapeutic perspective.

Seung Hyun Kim, Min-Young Noh, Matthew C Kiernan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular neurodegeneration, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seung Hyun Kim *Department of Neurology, College of Medicine, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. kimsh1@hanyang.ac.kr.
Min-Young Noh *Department of Neurology, College of Medicine, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.
Matthew C KiernanNeuroscience Research Australia, Barker St, Randwick, Sydney, NSW, 2031, Australia. matthew.kiernan@neura.edu.au.

Funding

the Korea Dementia Research Project through the Korea Dementia Research Center (KDRC) RS-2024-00348451
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antagonistic pleiotropyBiological constraintEvolutionary trade-offsNeurodegenerative diseasesResilience exhaustionSelective vulnerabilityTherapeutic paradigms

Identifiers

PMID42186051
PMCPMC13393241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.