Evidence map›Paper›PMID 42186044›Full record

ArticleBMC ophthalmology2026

Comparison of ocular biometric parameters between nanophthalmos and primary angle closure disease: a cross-sectional comparative study.

Sharmila Rajendrababu, Tos Tjm Berendschot, Vijayalakshmi A Senthilkumar, Udhayakumar Maghalakshmi, Mythri Krishnamurthy Rao, Balagiri Sundar, Carroll Andre Bertha Webers

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sharmila RajendrababuGlaucoma Services, Aravind Eye Hospital, No.72, Kuruvikaran Salai, Gandhi Nagar, Madurai, Tamil Nadu, 625020, India. shamsreddy@yahoo.com.
Tos Tjm BerendschotUniversity Eye Clinic Maastricht, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Vijayalakshmi A SenthilkumarGlaucoma Services, Aravind Eye Hospital, No.72, Kuruvikaran Salai, Gandhi Nagar, Madurai, Tamil Nadu, 625020, India.
Udhayakumar MaghalakshmiGlaucoma Services, Aravind Eye Hospital, No.72, Kuruvikaran Salai, Gandhi Nagar, Madurai, Tamil Nadu, 625020, India.
Mythri Krishnamurthy RaoGlaucoma Services, Aravind Eye Hospital, No.72, Kuruvikaran Salai, Gandhi Nagar, Madurai, Tamil Nadu, 625020, India.
Balagiri SundarLions Aravind Institute of Community Ophthalmology, Aravind Eye Care System, Madurai, India.
Carroll Andre Bertha WebersUniversity Eye Clinic Maastricht, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the ocular biometric parameters between eyes with nanophthalmos and primary angle closure disease (PACD).

methodsThis was a cross-sectional, comparative hospital-based study. A total of 144 subjects (144 eyes) including 58 nanophthalmos patients and 86 primary angle closure disease (26 primary angle closure and 60 primary angle closure glaucoma) patients were included in the study. The parameters studied were central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber angle (ACA), angle opening distance (AOD500 &AOD750), lens vault (LV), lens thickness (LT), axial length (AL), lens axial factor (LAF), relative lens position (RLP), and retinochoroido-scleral (RCS) thickness. All measurements were obtained prior to any laser or surgical intervention.

resultsThe mean ± SD age was comparable without any statistically significant difference across all the groups (57.3 ± 11 years in the nanopthalmos group,56.7 ± 9.3 years in the PAC group,56.1 ± 9.2 in the PACG group).The median IOP was highest in PAC eyes (17mmHg) followed by PACG eyes (16mmHg) and nanophthalmic eyes (14mmHg) (p = 0.003). A significant difference was found in ACA among the three groups (p = 0.003), PAC and PACG eyes exhibited wider angles (median 26

conclusionNanophthalmos represents a more anatomically crowded and complex entity compared to PACD, characterized by critical biometric alterations that predispose to severe angle closure. Comprehensive biometric evaluation is essential for early diagnosis, risk stratification, and individualized management planning in these eyes.

Indexed as

BiometryGlaucoma, Angle-ClosureMicrophthalmosAgedAnterior ChamberAxial Length, EyeCross-Sectional StudiesFemaleHumansIntraocular PressureLens, CrystallineMaleMiddle AgedAngle parametersLens parametersNanophthalmosOcular biometric parametersPrimary angle closure diseaseRetinochoroido- scleral thickness

Identifiers

PMID42186044
PMCPMC13390387

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