ArticleBMC endocrine disorders2026
Persistent oxidized regenerated cellulose mimicking locoregional recurrence after thyroidectomy: diagnostic challenges and associated risk factors.
Article in BMC endocrine disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOxidized regenerated cellulose (ORC) is widely used as a local hemostatic agent during thyroid surgery. Although manufacturers report complete absorption within 7-14 days, persistent ORC is frequently observed in postoperative follow-up, often mimicking residual or recurrent thyroid tissue. This misinterpretation can result in unnecessary investigations or biopsies. The present study aimed (1) to define the ultrasonographic features of persistent ORC to prevent misleading radiological interpretations and (2) to identify the risk factors associated with delayed ORC resorption.
methodsA retrospective review was conducted on 145 consecutive patients who underwent thyroid surgery between May 2022 and April 2024. Ultrasonographic follow-up findings were analyzed to identify persistent ORC. Potential clinical and hematological predictors of delayed absorption were evaluated. Statistical analyses included chi-square tests, t-tests, and Cox regression models to determine independent risk factors influencing ORC persistence.
resultsPersistence of ORC was significantly associated with a history of reoperation (p = 0.002), presence of coronary artery disease (p = 0.006), low neutrophil count (< 3.785 × 10⁹/L; p = 0.003), and the use of the Pahacel
conclusionsPersistent ORC may mimic recurrent thyroid tissue on postoperative imaging. Awareness of its ultrasonographic appearance and understanding of related risk factors are essential to avoid unnecessary diagnostic procedures. Surgeons, endocrinologists, and radiologists should exercise caution during postoperative assessment, especially in patients with risk factors for delayed absorption.
trial registrationThis study is a retrospective analysis and was not prospectively registered.
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