Evidence map›Paper›PMID 42185954›Full record

ArticleThe journal of headache and pain2026

Kappa opioid receptor availability correlates with depressive symptom burden in chronic migraine: a preliminary investigation.

Dajung J Kim, Majid Saberi, Tanpreet Kaur, Xia Shao, Robert A Koeppe, Peter J H Scott, Frank Porreca, Alexandre F DaSilva

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In one paragraph

Article in The journal of headache and pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Dajung J KimHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan, Ann Arbor, MI, 48109, USA.
Majid SaberiHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan, Ann Arbor, MI, 48109, USA.
Tanpreet KaurDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Xia ShaoDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Robert A KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Peter J H ScottDepartment of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Frank PorrecaDepartment of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ, 85721, USA.
Alexandre F DaSilvaHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan, Ann Arbor, MI, 48109, USA. adasilva@umich.edu.

Funding

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in vivo)R01NS094413 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALEXANDRE DASILVA · 2015 to 2026
$4.3M
Changwon National University New Faculty Research Support GrantNINDS NIH HHS R01 NS094413
6 · The paper itself

Abstract

backgroundChronic pain is frequently accompanied by affective disturbances, yet the neurobiological mechanisms linking pain perception and affective vulnerability remain poorly understood. The kappa opioid receptor (KOR)/dynorphin system has emerged as a key modulator of nociceptive and affective processes, in part through regulation of dopamine signaling within mesocorticolimbic circuits. However, the role of KOR signaling to pain-related affect and functional integration in migraine has not been characterized.

methodsWe measured KOR availability using positron emission tomography (PET) with [¹¹C]LY2795050, a selective KOR antagonist radioligand in 12 individuals with chronic migraine (CM; 11 F/1 M; 42.0 ± 15.1 years) and 11 healthy controls (HC; 9 F/2 M; 40.9 ± 17.0 years). PET scans included an early resting and late sustained thermal pain stimulus stress (STPTS) phase, with KOR availability quantified as non-displaceable binding potential (BP

resultsCompared with HC, individuals with CM showed significantly elevated KOR BP

conclusionsThese findings indicate altered fronto-insular KOR availability in individuals with CM and suggest that KOR signaling may contribute to affective symptom burden, even at subclinical levels. The observed associations between KOR availability and rs-fMRI measures warrant cautious interpretation and further investigation in larger samples.

Indexed as

BrainDepressionMigraine DisordersReceptors, Opioid, kappaAdultChronic DiseaseFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographySymptom BurdenReceptors, Opioid, kappaChronic migraineDepressive symptomInsulaKappa opioid receptorMultimodal neuroimagingPET

Identifiers

PMID42185954
PMCPMC13397754

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.