Evidence map›Paper›PMID 42185913›Full record

ArticleBiotechnology for biofuels and bioproducts2026

Engineering of a LysG-derived arginine-specific biosensor for high-throughput screening of arginine overproducers in Corynebacterium glutamicum.

Ningyun Cai, Ye Wang, Pengcheng Ren, Deming Rao, Tuo Shi, Ziyao Wang, Jie Shen, Wenjuan Zhou, Linlin Qi, Lixian Wang and 4 more

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In one paragraph

Article in Biotechnology for biofuels and bioproducts, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ningyun CaiCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Ye WangState Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin, 300308, China.
Pengcheng RenTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Deming RaoSchool of Life Science and Technology, Wuhan Polytechnic University, Wuhan, 430023, China.
Tuo ShiTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Ziyao WangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Jie ShenTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Wenjuan ZhouState Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin, 300308, China.
Linlin QiTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Lixian WangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Ning ChenCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Jiuzhou ChenState Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin, 300308, China. chen_jz@tib.cas.cn.
Ping ZhengCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China. zheng_p@tib.cas.cn.
Jibin SunState Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin, 300308, China.

Funding

National Key Research and Development Program of China 2024YFC3407100National Natural Science Foundation of China 32270101Tianjin Major Science and Technology Projects and Engineering Programs (Future Industry Projects) 25ZXWCSY00180
6 · The paper itself

Abstract

Arginine is a semi-essential amino acid and holds significant value in the pharmaceutical and nutraceutical industries. Corynebacterium glutamicum is a promising host for arginine production, yet its industrial titers remain limited. Biosensor-based high-throughput screening enables rapid isolation of overproducers. However, the native LysG-based biosensor in C. glutamicum lacks arginine specificity, limiting its efficiency for screening high arginine-producing strains. Here, we developed an arginine-specific biosensor pLysG

Indexed as

ArginineArginine-specific biosensorCorynebacterium glutamicumHigh-throughput screeningLysG

Identifiers

PMID42185913
PMCPMC13450260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.