Evidence map›Paper›PMID 42185775›Full record

ArticleThe journal of headache and pain2026

Shared genetic architecture between depression and migraine: a large-scale genome-wide cross-trait analysis.

Min Zhang, Qiyin Li, Yuan Zhao, Yadong Peng, Jiangyou Yu, Cheng Gan, Liwei Tang, Keyi Liu, Ying Liu, Zheng Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Min Zhang *Department of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Qiyin Li *Department of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Yuan ZhaoDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Yadong PengDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Jiangyou YuDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Cheng GanDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Liwei TangDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Keyi LiuDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Ying LiuDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Zheng ZhangDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Xinglian WangDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China.
Mingshuang TangDepartment of Epidemiology and Health Statistics, School of Public Health, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Chenggang JiangDepartment of Sleep and Psychology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China. jcgaqq@126.com.
Dongqing GuDepartment of Obstetrics and Gynecology, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), No. 120, Longshan Road, Longshan Street, Yubei District, Chongqing, 401147, China. gudongqing11@126.com.

Funding

Chongqing Science and Health Joint Medical Research Project 2026MSXM131National Natural Science Foundation of China 82504535Senior Medical Talents Program of Chongqing for Young and Middle-aged YXGD202401
6 · The paper itself

Abstract

backgroundDepression and migraine are highly prevalent neuropsychiatric disorders that frequently co-occur. However, the extent to which they share genetic determinants, particularly for postpartum depression (PPD), an underexplored subtype, remains insufficiently understood.

methodsWe performed a large-scale genome-wide cross-trait analysis using summary statistics for depression phenotypes (overall depression, major depressive disorder [MDD], PPD) and migraine subtypes (migraine, migraine with aura [MA], migraine without aura [MO]). Genetic correlations were estimated using linkage disequilibrium score regression (LDSC) and GNOVA. Pleiotropically associated loci were identified through cross-trait meta-analysis, followed by fine-mapping and colocalization analyses to prioritize potential loci with stronger evidence for shared causal signals. Functional annotation and gene-based analyses were conducted to explore biological relevance. Bidirectional and multivariable Mendelian randomization (MVMR) were applied to assess potential causal relationships.

resultsWe observed significant global and local genetic correlations between depression and migraine (LDSC r

conclusionsDepression and migraine show substantial genetic overlap and exhibit an asymmetric pattern of potential causal relationships, with stronger MR evidence for the depression-to-migraine direction than for the reverse direction. The pleiotropically associated loci provide genomic evidence for future mechanistic and translational investigation across depression and migraine subtypes. The findings also highlight PPD as a genetically related but potentially distinct subtype warranting further investigation.

Indexed as

Depression, PostpartumMajor Depressive DisorderMigraine DisordersGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansCross-trait analysisDepressionMendelian randomizationMigrainePleiotropic lociPostpartum depression

Identifiers

PMID42185775
PMCPMC13390404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.