Trial reportBMC geriatrics2026
Effect of cerebellar vermis intermittent theta-burst stimulation on balance function in frail older adults: a randomized controlled trial.
Trial report in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Target Interpretability and Functional Mapping of rTMS and Theta-Burst Stimulation of the Cerebellar Vermis and Midline Cerebellum: A Scoping Review.Cerebellum (London, England) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundWith the increasing population of frail older adults, their compromised balance functions pose risks of falls and mortality. Effectively enhancing balance function could mitigate adverse health outcomes. This study aimed to evaluate the effect of intermittent theta-burst stimulation (iTBS) on balance function in frail older adults.
methodsFourty-eight subjects were randomly assigned to receive iTBS and sham stimulation in a randomized control trial design over a period of 4 weeks. Before and after intervention, related balance evaluation data was collected, including berg balance scale (BBS) score, Time-up and go (TUG) test, Sensory Organization Test (SOT) and Limit of Stability (LOS) data obtained through the Balance Master system. Additionally, cortical activity was recorded using functional near-infrared spectroscopy (fNIRS), fNIRS was used as an exploratory neuroimaging measure. The Tilburg Frailty Indicator (TFI) was also assessed.
resultsA total of 45 subjects (mean [SD] age, 67.69 [8.16] years; 33 females [73.7%]) completed the trial were enrolled and randomized to receive iTBS (n = 23) or sham stimulation (n = 22). After intervention, the BBS (p<0.001), and TFI (p<0.001) score statistically significant improved in the iTBS group. The SOT (p<0.05) also improved. And the LOS had statistically significant improvement. However, no statistically significant difference was found in the Timed Up and Go (TUG) test between the two groups (p > 0.05). And study showed a significant difference in HbO levels for the left DLPFC (p < 0.05; 95% CI: -0.066, -0.003) and bilateral SMA (p<0.05, 95% CI: -0.061, -0.007; p<0.05, 95% CI: -0.072, -0.016) before and after the intervention. No significant adverse effects were reported on all subjects.
conclusionsOur findings indicate that iTBS could promote balance function, as evidenced by an increase in the BBS score, improvements in SOT and LOS, as well as elevated levels of oxygenated hemoglobin (HbO) in the dorsolateral prefrontal cortex (DLPFC) and supplementary motor area (SMA). CLINICAL TRIAL NUMBER: This clinical study was registered at Chinese Clinical Trial Registry (ChiCTR, ChiCTR2500097468; registered on 19/02/2025).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.