ArticlePest management science2026
Identification of acylhydrazone derivatives with isopropanolamine moiety as potent anti-virulence agents for combating bacterial infection.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundQuorum sensing (QS)-regulated virulence factors including biofilms are key drivers of phytopathogen pathogenicity and antimicrobial resistance. Unlike conventional bactericides that exert selective pressure leading to resistance evolution, anti-virulence agents offer a promising strategy to control bacterial diseases without promoting resistance, having significant potential in the creation of new bactericides.
resultsIn this study, hydroxybenzaldehyde was used as the starting material to synthesize a series of 39 novel acylhydrazone derivatives containing flexible isopropanolamine moieties. Among these, compound C19 exhibited excellent in vitro activity against the rice bacterial blight pathogens Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac), with in vitro EC
conclusionThis study successfully designed and synthesized a series of novel isopropanolamine-modified acylhydrazone derivatives as potent anti-virulence agents. Compound C19, with its excellent antibacterial activity, favorable safety profile and unique anti-virulence performance, represents a promising lead compound for the development of novel environmentally friendly bactericides to combat bacterial resistance. © 2026 Society of Chemical Industry.
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