Evidence map›Paper›PMID 42185750›Full record

ArticleHead & neck2026

Visualization of Scattered Tumor Regression Following Neoadjuvant Chemoimmunotherapy With a Novel Intraoperative PET/CT Scanner.

Andreja Radevic, Joaquin Austerlitz, Ashtyn McAdoo, Kyrionna Golliday, Takeshi Takahashi, Mitra Mehrad, Adam J Rosenberg, Barbara A Murphy, Eben Rosenthal, Michael C Topf

Registry-linked trialAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06915454 (High-resolution Specimen PET-CT Imaging for the Intraoperative Visualization of Resection Margins), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06915454 narecruitingnot on this map

High-resolution Specimen PET-CT Imaging for the Intraoperative Visualization of Resection Margins: an Exploratory Study

TypeinterventionalSponsorVanderbilt-Ingram Cancer CenterRan2025 to 2027Enrolled50ConditionsCancer, Solid Malignant Tumors, SCC - Squamous Cell Carcinoma, HNSCCArmsIntra-op PET/CT Specimen Scanner
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andreja RadevicDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Joaquin AusterlitzDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-5554-7933
Ashtyn McAdooDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kyrionna GollidayDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Takeshi TakahashiDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mitra MehradDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-4180-8180
Adam J RosenbergVanderbilt University Institute of Imaging Science, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-2459-7043
Barbara A MurphyDivision of Hematology and Oncology, Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA.
Eben RosenthalDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Michael C TopfDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-1022-4417

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Augmented Reality to Guide Head and Neck Cancer SurgeryK08CA293255 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Michael Topf · 2024 to 2026
$645k
NCI NIH HHS 5K08CA293255-02NCI NIH HHS K08 CA293255NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

backgroundNeoadjuvant chemoimmunotherapy is being explored in locally advanced head and neck squamous cell carcinoma (HNSCC), yet the spatial patterns of pathologic response and clinical implications remain poorly characterized.

methodsA 79-year-old female with recurrent left oral tongue SCC (PD-L122C3 Combined Positive Score 90) who underwent prior resection and free flap reconstruction received neoadjuvant pembrolizumab, paclitaxel, and carboplatin followed by definitive surgical resection with intraoperative positron emission tomography/computed tomography (PET/CT) imaging.

resultsFinal histopathology revealed two discrete foci of residual poorly differentiated SCC, measuring 1.8 and 0.5 cm, separated by an 8 mm intervening bridge of inflammation without viable tumor. Intraoperative PET/CT with 3D specimen mapping confirmed the spatial relationship between residual foci and intervening treatment effect.

conclusionsPathologic response to neoadjuvant chemoimmunotherapy in HNSCC can manifest as a multifocal regression pattern. Intraoperative real-time approaches to assessing treatment response warrant further investigation.

trial registrationClinicalTrials.gov identifier: NCT06915454.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Squamous CellImmunotherapyNeoadjuvant TherapyPositron Emission Tomography Computed TomographySquamous Cell Carcinoma of Head and NeckTongue NeoplasmsAgedAntibodies, Monoclonal, HumanizedCarboplatinFemaleHumansNeoplasm Recurrence, LocalPaclitaxelPathologic Complete ResponseTreatment OutcomeAntibodies, Monoclonal, HumanizedCarboplatinPaclitaxelpembrolizumabhead and neck squamous cell carcinomaintraoperative PET/CTneoadjuvant chemoimmunotherapypathologic responsetumor regression pattern

Identifiers

PMID42185750
PMCPMC13445472

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.