ArticleInternational journal of colorectal disease2026
Gut microbiota profiles in reactive and metastatic lymphadenopathy in colorectal cancer: a tumor location-stratified analysis.
Article in International journal of colorectal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePreoperative lymphadenopathy in colorectal cancer may represent nodal metastasis or reactive change. We aimed to compare gut microbiota profiles between reactive and metastatic lymphadenopathy and to explore microbial features associated with nonmetastatic lymph node enlargement.
methodsWe conducted a retrospective observational study of colorectal cancer patients with radiological lymphadenopathy who underwent resection at Shiga University of Medical Science Hospital between 2018 and 2021. For the primary analysis, we included patients with radiological lymphadenopathy on preoperative CT. An additional analysis restricted to right-sided colon cancer compared no lymphadenopathy without pathological lymph node metastasis (NN), lymphadenopathy without pathological lymph node metastasis (PN), and lymphadenopathy with pathological lymph node metastasis (PP).
resultsPathological nodal metastasis was identified in 34 patients, whereas 29 had reactive lymphadenopathy. Fecal samples showed higher alpha diversity than tumor tissues. In left-sided colorectal cancer, no notable bacterial taxa exceeded the predefined LDA threshold. In right-sided colon cancer, Proteobacteria were enriched in metastatic cases, whereas Firmicutes were more abundant in reactive lymphadenopathy. Predicted pathway analysis suggested distinct metabolic profiles between the two groups. In the additional right-sided analysis, alpha and beta diversity did not significantly differ among NN, PN, and PP, although taxon-level differences were observed between NN and PN.
conclusionGut microbiota profiles differed between reactive and metastatic lymphadenopathy in colorectal cancer, with more distinct findings in right-sided tumors. These findings suggest an association between microbial patterns and reactive lymphadenopathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.