ArticleScientific reports2026
A closed‑form reaction‑kinetics model for LET‑ and oxygen‑dependent hydroxyl radical availability under irradiation.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The biological effectiveness of ionizing radiation depends not only on absorbed dose but also on radiation quality and microenvironmental factors, particularly linear energy transfer (LET) and oxygenation. Although Monte Carlo track-structure simulations can describe radiation-matter interactions in detail, such complexity often obscures the individual roles played by governing parameters. We present here a closed-form, analytical reaction-kinetics model for the indirect chemical stage of radiation action. The model introduces an LET-dependent source term for hydroxyl radical production based on experimentally and computationally established G-value trends and combines it with a balance equation derived from a directional Boltzmann-P
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