Evidence map›Paper›PMID 42185588›Full record

ArticleGeroScience2026

TTV virome marks immune exhaustion, α7nAChR alteration, and mortality in elderly patients with severe COPD.

Laura Vitiello, Stefania Proietti, Dolores Limongi, Carla Prezioso, Paola Checconi, Paola Fortugno, Marco Quaranta, Fabrizio Maggi, Guido Antonelli, Stefano Bonassi and 1 more

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura VitielloDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, Via di Val Cannuta 247, 00166, Rome, Italy.ORCID http://orcid.org/0000-0003-0776-3601
Stefania ProiettiAgEA Coordinating Body, Rome, Italy.ORCID http://orcid.org/0000-0002-9844-1482
Dolores LimongiDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, Via di Val Cannuta 247, 00166, Rome, Italy.ORCID http://orcid.org/0000-0003-2095-8112
Carla PreziosoDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, Via di Val Cannuta 247, 00166, Rome, Italy.ORCID http://orcid.org/0000-0002-8377-0742
Paola ChecconiDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, Via di Val Cannuta 247, 00166, Rome, Italy.ORCID http://orcid.org/0000-0001-7518-5730
Paola FortugnoDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, Via di Val Cannuta 247, 00166, Rome, Italy.ORCID http://orcid.org/0000-0002-0151-6477
Marco QuarantaDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, Via di Val Cannuta 247, 00166, Rome, Italy.
Fabrizio MaggiNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.ORCID http://orcid.org/0000-0001-7489-5271
Guido AntonelliDepartment of Molecular Medicine, Sapienza University, 00185, Rome, Italy.ORCID http://orcid.org/0000-0002-2533-2939
Stefano BonassiDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, Via di Val Cannuta 247, 00166, Rome, Italy.ORCID http://orcid.org/0000-0003-3833-6717
Patrizia RussoDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele Roma University, Via di Val Cannuta 247, 00166, Rome, Italy. patrizia.russo@uniroma5.it.ORCID http://orcid.org/0000-0003-1745-7827

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca B53D23003760006Ministero dell'Università e della Ricerca G53D23000700001
6 · The paper itself

Abstract

Torque teno virus (TTV) viremia, part of the human virome, is emerging as a dynamic marker of immune competence, yet its links to immune exhaustion, cholinergic dysfunction, and poor outcomes in elderly patients with severe COPD remain unclear. In 102 elderly COPD patients (age 72.6 ± 8.8 years, GOLD stage 3-4) undergoing a 3-week pulmonary rehabilitation program, TTV load was measured, and peripheral blood mononuclear cells were analyzed for T-cell subsets and α7 nicotinic acetylcholine receptor (α7nAChR) expression. Patients with high TTV load (≥ 4 log

Indexed as

COPD-elderly patientsImmune dysregulationRehabilitationSurvivalTTVα7nAChR

Identifiers

PMID42185588

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.