Evidence map›Paper›PMID 42185562›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Quality by design based development and optimization of a thermoreversible in situ intranasal gel of zavegepant for nose to brain delivery in migraine therapy.

Anil Pawar, Vishal Balme, Ramdas Pandhare, Vinayak Deshmukh, Babasaheb Bhagat, Santosh Belhekar, Vaibhav Andhale

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anil PawarMula Education Society's College of Pharmacy, Sonai, Ahilyanagar, India. anilpharma123@gmail.com.
Vishal BalmeMula Education Society's College of Pharmacy, Sonai, Ahilyanagar, India.ORCID http://orcid.org/0009-0002-5286-4030
Ramdas PandhareMula Education Society's College of Pharmacy, Sonai, Ahilyanagar, India.
Vinayak DeshmukhMula Education Society's College of Pharmacy, Sonai, Ahilyanagar, India.
Babasaheb BhagatDVVPF's, College of Pharmacy, Vildad Ghat, Ahilyanagar, Maharashtra, India.
Santosh BelhekarGourishankar Institute of Pharmaceutical Education & Research, Satara, India.
Vaibhav AndhalePravara Rural College of Pharmacy, Pravaranagar, Loni, India. vaibhav.dmandhale@gmail.com.ORCID http://orcid.org/0009-0007-4782-1614

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to develop and optimize a thermoreversible in-situ nasal gel of Zavegepant for effective and rapid treatment of acute migraine, enhancing brain targeting and bioavailability while overcoming limitations of oral formulations. A 3

Indexed as

BrainMigraine DisordersAdministration, IntranasalAnimalsDisease Models, AnimalDrug Delivery SystemsDrug LiberationGelsMaleNasal MucosaPoloxamerRatsRats, Sprague-DawleyTemperatureGelsPoloxamerCGRP antagonistFactorial designIn-situ nasal gelIntranasal deliveryMigrainePharmacodynamicsThermoreversible gelZavegepant

Identifiers

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Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.