Bio inspired assessment of titanium-organic framework and exosome-constructed p-Synephrine carriage: pursuing the PI3K/mTOR pathway in a simulated periodontitis.

Mohamed S Kishta, Abdelrahman H Elshaar, Rawan N Makled, Ghada A Abdel-Aleem, Mirhan N Makled, Reda M Abdelhameed

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed S KishtaResearcher of medical biotechnology, Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El Buhouth St., El Dokki, P.O.B: 12622, Cairo, Egypt. kishtamsa@gmail.com.

Abdelrahman H ElshaarFaculty of Oral and Dental Medicine, Future University, Cairo, Egypt.

Rawan N MakledMansoura Manchester Dental programme, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.

Ghada A Abdel-AleemMedical Biochemistry Department, Faculty of Medicine, Tanta University, El Gharbia, Egypt.

Mirhan N MakledPharmacology and Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Reda M AbdelhameedApplied Organic Chemistry Department, Chemical Industries Research Institute, National Research Centre, 33 EL Buhouth St.,Dokki, Giza, 12311, Egypt. reda_nrc@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis, a chronic inflammatory disease, is driven by bacterial infection and oxidative stress, leading to tissue destruction and potential tooth loss. This study investigates the anti-inflammatory and antioxidant potential of p-Synephrine and enhanced delivery through NH

Indexed as

ExosomesPeriodontitisPhosphatidylinositol 3-KinasesTitaniumTOR Serine-Threonine KinasesAntioxidantsCells, CulturedCytokinesDental PulpFibroblastsGingivaHumansKeratinocytesOxidative StressSignal TransductionStem CellsAntioxidantsCytokinesMTOR protein, humanPhosphatidylinositol 3-KinasesTitaniumTOR Serine-Threonine KinasesDental pulp stem cells (DPSCs)ExosomesMIL-125Periodontitisp-Synephrine

Identifiers

PMID42185524

DOI10.1038/s41598-026-54070-6

PMCPMC13201600

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.