Evidence map›Paper›PMID 42185508›Full record

ArticleScientific reports2026

Synthesis and evaluation of vanillin-based sulfonates as potent α-glucosidase inhibitors through in vitro, in vivo, and in silico approaches.

Manel Essid, Ehsan Ullah Mughal, Nafeesa Naeem, Aneela Shaheen Cheema, Bushra Shakoor, Ishtiaq Ahmed, Charlene Marais, Amina Sadiq, Samar Y Al Nami, Aisha Hossan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Manel EssidChemistry Department, College of Science, King Khalid University (KKU), P.O. Box 9004, 61413, Abha, Saudi Arabia.
Ehsan Ullah MughalDepartment of Chemistry, University of Gujrat, Gujrat, 50700, Pakistan. ehsan.ullah@uog.edu.pk.
Nafeesa NaeemDepartment of Chemistry, University of Gujrat, Gujrat, 50700, Pakistan.
Aneela Shaheen CheemaDepartment of Chemistry, University of Gujrat, Gujrat, 50700, Pakistan.
Bushra ShakoorSynthetic & Natural Product Discovery Lab., Department of Chemistry, Government College Women University Faisalabad, Faisalabad, 38000, Pakistan.
Ishtiaq AhmedDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Charlene MaraisDepartment of Chemistry, University of the Free State, P.O. Box 339, Bloemfontein, 9300, South Africa.
Amina SadiqDepartment of Chemistry, Govt. College Women University, Sialkot, 51300, Pakistan.
Samar Y Al NamiDepartment of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia.
Aisha HossanDepartment of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia.

Funding

King Khalid University, Saudi Arabia RGP2/148/46
6 · The paper itself

Abstract

In the present study, a series of structurally diverse vanillin sulfonate derivatives (1-9) were synthesized and evaluated as potential α-glucosidase inhibitors through integrated in vitro, in vivo, and in silico approaches. The target compounds were obtained via sulfonation and subsequent functional modification of the vanillin scaffold and were fully characterized using standard spectroscopic techniques. Enzyme inhibition assays demonstrated that several derivatives exhibited strong α-glucosidase inhibitory activity, with inhibitory constants significantly lower than that of the reference drug, indicating enhanced potency. The synthesized compounds showed notable α-glucosidase inhibitory activity, with compounds 8 (IC

Indexed as

alpha-GlucosidasesBenzaldehydesGlycoside Hydrolase InhibitorsHypoglycemic AgentsSulfonic AcidsAnimalsHumansMolecular Docking SimulationStructure-Activity Relationshipalpha-GlucosidasesBenzaldehydesGlycoside Hydrolase InhibitorsHypoglycemic AgentsSulfonic AcidsvanillinADMETDFTIn vitroIn vivoMD simulationMolecular dockingVanillin sulfonatesα-Glucosidase

Identifiers

PMID42185508
PMCPMC13434683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.