Evidence map›Paper›PMID 42185467›Full record

ArticleNature immunology2026

Thymic alveolar type 2 epithelial mimetic cells revealed by RUNX1 deficiency.

Jun Hyung Sin, Christopher J Bowman, Joe Germino, Sloan H Phillips, Juliana Sucharov, Xian Liu, Yi Wang, Corey N Miller, Audrey V Parent, Aaron Bodansky and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jun Hyung SinBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Christopher J BowmanDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4107-4116
Joe GerminoBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3939-3342
Sloan H PhillipsDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0008-5566-6121
Juliana SucharovBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Xian LiuBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Yi WangDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Corey N MillerDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1291-0074
Audrey V ParentDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-4506-6268
Aaron BodanskyDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Mark S AndersonDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3093-4758
Michael R WaterfieldBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. michael.waterfield@ucsf.edu.ORCID http://orcid.org/0000-0003-1950-9379

Funding

Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher · 2020 to 2026
$4.5M
Regulation of medullary thymic epithelial cells and thymic central tolerance by IkarosR01AI165829 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Michael R Waterfield · 2023 to 2026
$2.7M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) R01AI165829NIAID NIH HHS R01 AI165829NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

Autoimmune diseases can affect the lungs, and the mechanisms used to prevent autoimmune lung disease are incompletely understood. Recent studies in the thymus have identified unique populations of medullary thymic epithelial cells (mTECs) called mimetic cells that transcriptionally mimic peripheral epithelial populations. These mimetic cells have important functions in the thymus in immune tolerance. Here, we used a mouse line with thymic-specific deletion of Runt-related transcription factor 1 (Runx1) to identify a new mimetic cell akin to alveolar type 2 (AT2) lung epithelial cells. AT2 mTECs express surfactant genes, and with Runx1 deletion AT2 mTECs expand, resulting in a loss of AIRE

Indexed as

Alveolar Epithelial CellsCore Binding Factor Alpha 2 SubunitEpithelial CellsThymus GlandAIRE ProteinAnimalsErbB ReceptorsMiceMice, KnockoutSignal TransductionTranscription FactorsAIRE ProteinCore Binding Factor Alpha 2 SubunitErbB ReceptorsRunx1 protein, mouseTranscription Factors

Identifiers

PMID42185467
PMCPMC13341010

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.