Evidence map›Paper›PMID 42185395›Full record

ArticleScientific reports2026

Perovskone, a potential antiprotozoal hit compound, quantification and derivatization.

Mona Kamelan Zargar Zarin, Mahdi Moridi Farimani, Marzieh Tabefam, Mostafa Alilou, Farzaneh Azargoon, Marzieh Omrani, Marcel Kaiser, Peyman Salehi

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mona Kamelan Zargar ZarinDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, 1983969411, Tehran, Iran.
Mahdi Moridi FarimaniDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, 1983969411, Tehran, Iran. m_moridi@sbu.ac.ir.
Marzieh TabefamDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, 1983969411, Tehran, Iran.
Mostafa AlilouInstitute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck (CMBI), Universität Innsbruck, Innrain 80/82, Innsbruck, 6020, Austria.
Farzaneh AzargoonDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, 1983969411, Tehran, Iran.
Marzieh OmraniDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, 1983969411, Tehran, Iran.
Marcel KaiserSwiss Tropical and Public Health Institute, Socinstrasse 57, Basel, 4002, Switzerland.
Peyman SalehiDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, 1983969411, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perovskone is a structurally fascinating and intricate isoprenoid with significant antiprotozoal activities. This study quantified perovskone in various parts of its primary source, Salvia hydrangea, collected from two distinct climatic regions over three years. Its quantity was also assessed in three other Salvia species that are taxonomically close to S. hydrangea. Moreover, semi-synthetic derivatives (3-5) were synthesized from perovskoneto improve its antiparasitic capabilities. 1D and 2D NMR and HRMS were used to identify the structures, and perovskone to then the compounds were evaluated in vitro against Leishmania donovani, Trypanosoma brucei, Plasmodium falciparum, and Trypanosoma cruzi and cytotoxicity was assessed in rat L6 skeletal myoblasts. Perovskone was the highest in S. hydrangea leaves and stems at 0.053% dry weight (1.5% dry extract), followed by flowers at 0.04% of dry weight. It was below the limit of quantification (LOQ) in roots and in other Salvia species. No significant difference was observed between samples of different years. Derivative 3 demonstrated significant efficacy against P. falciparum (IC

Indexed as

Antiprotozoal AgentsSalviaTerpenesAnimalsLeishmania donovaniMyoblasts, SkeletalPlant ExtractsPlasmodium falciparumRatsTrypanosoma brucei bruceiTrypanosoma cruziAntiprotozoal AgentsPlant ExtractsTerpenesAntiprotozoal activityBioactive isoprenoidsPerovskoneSalvia hydrangeaSemi-synthetic derivatives

Identifiers

PMID42185395
PMCPMC13434005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.