Evidence map›Paper›PMID 42185338›Full record

ArticleNPJ Parkinson's disease2026

Depression in Parkinson's disease is associated with reduced ventral striatal dopamine transporter binding.

Jessica E M C Dirkx, Filip Grill, Nienke Dijk, Roshan Cools, Jan Booij, Bastiaan R Bloem, Rick C G Helmich, Henricus G Ruhé, Maria H C T van Beek

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica E M C DirkxDepartment of Psychiatry, Radboud University Medical Centre (Radboudumc), Nijmegen, the Netherlands. Jessica.dirkx@radboudumc.nl.
Filip GrillDonders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, the Netherlands.
Nienke DijkDepartment of Psychiatry, Radboud University Medical Centre (Radboudumc), Nijmegen, the Netherlands.
Roshan CoolsDepartment of Psychiatry, Radboud University Medical Centre (Radboudumc), Nijmegen, the Netherlands.
Jan BooijDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands.
Bastiaan R BloemDonders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, the Netherlands.
Rick C G HelmichDonders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, the Netherlands.
Henricus G RuhéDepartment of Psychiatry, Radboud University Medical Centre (Radboudumc), Nijmegen, the Netherlands.
Maria H C T van BeekDepartment of Psychiatry, Radboud University Medical Centre (Radboudumc), Nijmegen, the Netherlands.

Funding

Congressionally Directed Medical Research Programs W81XWH-19-1-0713
6 · The paper itself

Abstract

Major depressive disorder (MDD) is a common non-motor symptom in Parkinson's disease (PD), affecting one third of patients. Dopaminergic deficits have been hypothesised to contribute to PD-MDD, but direct molecular evidence is limited. In this cross-sectional study, we compared striatal dopamine transporter (DAT) binding between 22 depressed (DSM-5) and 34 well-matched non-depressed PD patients using [

Identifiers

PMID42185338
PMCPMC13550646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.